Difluoromethylornithine rebalances aberrant polyamine ratios in Snyder-Robinson syndrome: mechanism of action and therapeutic potential
T. R. M. Stewart, J. R. Foley, C. E. Holbert, M. A. Khomutov, N. Rastkari, X. Tao, A. R. Khomutov, R. G. Zhai, R. A. Casero
This study shows DFMO rebalances polyamine ratios in SRS patient cells and extends lifespan in a Drosophila model, suggesting therapeutic potential for SRS.
bioRxiv · Mar 30, 2023Biochemistry