Author

J. R. Lazzari-Dean

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Organism:human· 2 Research Focus:differential expression· 1 Approach:experimental assay· 1 Assay:fluorescence / live-cell microscopy· 1 Approach:genetic perturbation / CRISPR· 1 Assay:imaging· 1 Approach:microscopy & imaging analysis· 1

Frequent Co-Authors

A. M. M. Gest· 2 shared B. D. Bennett· 1 shared C. H. Jan· 1 shared E. Miller· 1 shared E. W. Miller· 1 shared F. McAllister· 1 shared G. Ortiz· 1 shared J. E. Villalta· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersPhysiology

A. M. M. Gest

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

A red-emitting carborhodamine for monitoring and measuring membrane potential

A. M. M. Gest, J. R. Lazzari-Dean, G. Ortiz, S. K. Yaeger-Weiss, S. C. Boggess, E. W. Miller

This paper introduces a new red-emitting fluorescent indicator, CRhOMe, capable of both monitoring and measuring membrane potentials with improved signal-to-noise and quantification using fluorescence lifetime imaging microscopy.

bioRxiv · Oct 6, 2023Physiology

Impairment of lipid homeostasis causes lysosomal accumulation of endogenous protein aggregates through ESCRT disruption

J. Yong, J. E. Villalta, N. Vu, M. A. Kukurugya, N. Olsson, M. P. Lopez, J. R. Lazzari-Dean, K. Hake, F. McAllister, B. D. Bennett, C. H. Jan

The paper identifies lipid homeostasis as a regulator of proteostasis, showing that lipid dysregulation disrupts ESCRT function and causes lysosomal protein aggregation.

bioRxiv · Nov 23, 2022 · PreprintCell Biology

Optical determination of absolute membrane potential

J. R. Lazzari-Dean, A. M. M. Gest, E. Miller

The paper develops a fluorescence lifetime-based method to optically measure absolute membrane potential in cells and demonstrates its application in human carcinoma cells.

bioRxiv · Jan 14, 2019 · PreprintPhysiology