Human pseudoislet system enables detection of differences in G-protein-coupled-receptor signaling pathways between α and β cells
J. T. Walker, R. Haliyur, H. A. Nelson, M. Ishahak, G. Poffenberger, R. Aramandla, C. Reihsmann, J. R. Luchsinger, D. C. Saunders, P. Wang, A. Garcia-Ocana, R. Bottino, A. Agarwal, A. C. Powers, M. Brissova
The paper develops a pseudoislet system to study GPCR signaling differences between human α and β cells, showing distinct effects of Gi and Gq pathway activations on hormone secretion.
bioRxiv · Nov 14, 2019Cell Biology