A. C. Powers

Pancreatic islet α cell function and proliferation requires the arginine transporter SLC7A2

This study identifies SLC7A2 as essential for α cell proliferation and glucagon secretion, linking arginine transport to metabolic regulation and HbA1c variation.

Improving stem cell-derived pancreatic islets using single-cell multiome-inferred regulomes

The paper analyzes single-cell data to understand gene regulation in stem cell-derived pancreatic islets and identifies factors affecting beta-cell maturation and proliferation.

RFX6-mediated dysregulation defines human β cell dysfunction in early type 2 diabetes

This study identifies RFX6 as a key regulator of β cell dysfunction in early type 2 diabetes through multi-omics analysis of human pancreatic tissue.

SARS-CoV-2 Cell Entry Factors ACE2 and TMPRSS2 are Expressed in the Pancreas but are Not Enriched in Islet Endocrine Cells

The paper examines ACE2 and TMPRSS2 expression in the human pancreas and finds they are not enriched in islet endocrine cells, suggesting SARS-CoV-2 may not directly infect beta cells through these proteins.

Pancreatlas: applying an adaptable framework to map the human pancreas in health and disease

Pancreatlas provides a web resource for exploring annotated human pancreas images, integrating multiple imaging technologies into an adaptable framework for data access and analysis.

Human pseudoislet system enables detection of differences in G-protein-coupled-receptor signaling pathways between α and β cells

The paper develops a pseudoislet system to study GPCR signaling differences between human α and β cells, showing distinct effects of Gi and Gq pathway activations on hormone secretion.