M. Brissova

RFX6-mediated dysregulation defines human β cell dysfunction in early type 2 diabetes

This study identifies RFX6 as a key regulator of β cell dysfunction in early type 2 diabetes through multi-omics analysis of human pancreatic tissue.

Alpha cell dysfunction in early type 1 diabetes

The paper identifies early alpha cell dysfunction in individuals with GADA+ status, preceding beta cell loss in T1D, and links it to metabolic pathway abnormalities.

SARS-CoV-2 Cell Entry Factors ACE2 and TMPRSS2 are Expressed in the Pancreas but are Not Enriched in Islet Endocrine Cells

The paper examines ACE2 and TMPRSS2 expression in the human pancreas and finds they are not enriched in islet endocrine cells, suggesting SARS-CoV-2 may not directly infect beta cells through these proteins.

Coordinated interactions between endothelial cells and macrophages in the islet microenvironment promote beta cell regeneration

Pancreatlas: applying an adaptable framework to map the human pancreas in health and disease

Pancreatlas provides a web resource for exploring annotated human pancreas images, integrating multiple imaging technologies into an adaptable framework for data access and analysis.

Human pseudoislet system enables detection of differences in G-protein-coupled-receptor signaling pathways between α and β cells

The paper develops a pseudoislet system to study GPCR signaling differences between human α and β cells, showing distinct effects of Gi and Gq pathway activations on hormone secretion.