Author

M. Ishahak

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Organism:human· 3 Assay:scRNA-seq· 2 Assay:ATAC-seq· 1 Research Focus:cell signaling & trafficking· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1

Frequent Co-Authors

J. R. Millman· 2 shared M. D. Schmidt· 2 shared P. Augsornworawat· 2 shared A. Agarwal· 1 shared A. C. Powers· 1 shared A. Garcia-Ocana· 1 shared C. Reihsmann· 1 shared D. A. Veronese-Paniagua· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersCell Biology

J. R. Millman

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3 papers

Recent·Most cited

Comparative and Integrative Single Cell Analysis Reveals New Insights into the Transcriptional Immaturity of Stem Cell-Derived β Cells

M. D. Schmidt, M. Ishahak, P. Augsornworawat, J. R. Millman

This study compares SC-β cells with fetal and adult β cells using single-cell sequencing, finding they share a core β-cell identity but have unique transcriptional profiles with neural-biased gene networks.

bioRxiv · Nov 15, 2023Cell Biology

Defining the chromatin and transcriptional landscape of stem cell-derived islets

P. Augsornworawat, N. J. Hogrebe, M. Ishahak, E. Marquez, M. M. Maestas, M. D. Schmidt, D. A. Veronese-Paniagua, S. E. Gale, J. R. Miller, L. Velazco-Cruz, J. R. Millman

This study uses single-cell multiomic sequencing to analyze chromatin accessibility and transcriptional profiles of stem cell-derived islets, revealing differences in cell identity and chromatin state compared to primary human islets.

bioRxiv · Feb 26, 2022Cell Biology

Human pseudoislet system enables detection of differences in G-protein-coupled-receptor signaling pathways between α and β cells

J. T. Walker, R. Haliyur, H. A. Nelson, M. Ishahak, G. Poffenberger, R. Aramandla, C. Reihsmann, J. R. Luchsinger, D. C. Saunders, P. Wang, A. Garcia-Ocana, R. Bottino, A. Agarwal, A. C. Powers, M. Brissova

The paper develops a pseudoislet system to study GPCR signaling differences between human α and β cells, showing distinct effects of Gi and Gq pathway activations on hormone secretion.

bioRxiv · Nov 14, 2019Cell Biology