Author

R. Bottino

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Assay:proteomics· 2 Approach:statistical model· 2 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

A. C. Powers· 3 shared D. C. Saunders· 3 shared M. Brissova· 3 shared R. Aramandla· 3 shared C. Dai· 2 shared G. Poffenberger· 2 shared J. T. Walker· 2 shared R. Jenkins· 2 shared

Activity by Year

2019-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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3 shared papersCell Biology

A. C. Powers

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Author profile →

3 papers

Recent·Most cited

RFX6-mediated dysregulation defines human β cell dysfunction in early type 2 diabetes

J. T. Walker, D. C. Saunders, V. Rai, C. Dai, P. Orchard, A. L. Hopkirk, C. V. Reihsmann, Y. Tao, S. Fan, S. Shrestha, A. Varshney, J. J. Wright, Y. D. Pettway, C. Ventresca, S. Agarwala, , M. Brissova

This study identifies RFX6 as a key regulator of β cell dysfunction in early type 2 diabetes through multi-omics analysis of human pancreatic tissue.

bioRxiv · Dec 16, 2021Cell Biology

SARS-CoV-2 Cell Entry Factors ACE2 and TMPRSS2 are Expressed in the Pancreas but are Not Enriched in Islet Endocrine Cells

K. C. Coate, J. Cha, S. Shrestha, W. Wang, L. M. Goncalves, J. Almaca, M. E. Kapp, M. Fasolino, A. Morgan, C. Dai, D. C. Saunders, R. Bottino, R. Aramandla, R. Jenkins, R. Stein, , A. C. Powers

The paper examines ACE2 and TMPRSS2 expression in the human pancreas and finds they are not enriched in islet endocrine cells, suggesting SARS-CoV-2 may not directly infect beta cells through these proteins.

bioRxiv · Aug 31, 2020 · PreprintCell Biology

Human pseudoislet system enables detection of differences in G-protein-coupled-receptor signaling pathways between α and β cells

J. T. Walker, R. Haliyur, H. A. Nelson, M. Ishahak, G. Poffenberger, R. Aramandla, C. Reihsmann, J. R. Luchsinger, D. C. Saunders, P. Wang, A. Garcia-Ocana, R. Bottino, A. Agarwal, A. C. Powers, M. Brissova

The paper develops a pseudoislet system to study GPCR signaling differences between human α and β cells, showing distinct effects of Gi and Gq pathway activations on hormone secretion.

bioRxiv · Nov 14, 2019Cell Biology