SARS-CoV-2 Spike protein promotes hyper-inflammatory response that can be ameliorated by Spike-antagonistic peptide and FDA-approved ER stress and MAP kinase inhibitors in vitro
A. C.-Y. Hsu, G. Wang, A. T. Reid, P. C. Veerati, P. S. Pathinayake, K. Daly, J. R. Mayall, P. M. Hansbro, J. C. Horvat, F. Wang, P. A. Wark
This study shows that SARS-CoV-2 spike protein induces inflammation and epithelial damage, which can be reduced by an antagonistic peptide and FDA-approved drugs.
bioRxiv · Sep 30, 2020 · PreprintImmunology