Author

P. S. Pathinayake

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Immunology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:differential expression· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

A. T. Reid· 3 shared P. A. Wark· 3 shared P. C. Veerati· 3 shared P. M. Hansbro· 3 shared J. C. Horvat· 2 shared K. S. Nichol· 2 shared A. C.-Y. Hsu· 1 shared A. Reid· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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3 shared papersImmunology

A. T. Reid

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Comparison of commercially available differentiation media on morphology, function, and virus-host interaction in conditionally reprogrammed human bronchial epithelial cells

N. T. Awatade, A. T. Reid, K. S. Nichol, K. F. Budden, P. C. Veerati, P. S. Pathinayake, C. L. Grainge, P. M. Hansbro, P. A. Wark

This study compares two differentiation media for conditionally reprogrammed human bronchial epithelial cells, finding structural and functional differences but no impact on viral infection outcomes.

bioRxiv · Apr 12, 2023 · PreprintCell Biology

Single cell RNA-seq identifies inflammation-induced loss of CFTR-expressing airway ionocytes in non-eosinophilic asthma

L. Chen, G. A. Hoefel, P. S. Pathinayake, A. Reid, C. Kelly, T. HuiYing, R. Y. Kim, P. M. Hansbro, S. L. Brody, P. S. Foster, J. C. Horvat, C. Riveros, P. A. Wark, G. E. Kaiko

This study identifies inflammation-induced loss of CFTR-expressing ionocytes in non-eosinophilic asthma using single-cell RNA-seq and confirms it in human and murine models.

bioRxiv · Apr 26, 2022 · PreprintCell Biology

SARS-CoV-2 Spike protein promotes hyper-inflammatory response that can be ameliorated by Spike-antagonistic peptide and FDA-approved ER stress and MAP kinase inhibitors in vitro

A. C.-Y. Hsu, G. Wang, A. T. Reid, P. C. Veerati, P. S. Pathinayake, K. Daly, J. R. Mayall, P. M. Hansbro, J. C. Horvat, F. Wang, P. A. Wark

This study shows that SARS-CoV-2 spike protein induces inflammation and epithelial damage, which can be reduced by an antagonistic peptide and FDA-approved drugs.

bioRxiv · Sep 30, 2020 · PreprintImmunology

Anti-microbial immunity is impaired in COPD patients with frequent exacerbations

A. Singanayagam, S.-L. Loo, M. Calderazzo, L. J. Finney, M.-B. Trujillo-Torralbo, E. Bakhsoliani, J. L. Girkin, P. C. Veerati, P. S. Pathinayake, K. S. Nichol, A. T. Reid, J. Footitt, S. L. Johnston, N. Bartlett, P. Mallia

This study identifies impaired anti-viral and anti-microbial immunity in COPD patients with frequent exacerbations, linking reduced interferon and MBL-2 levels to increased bacterial loads and susceptibility to exacerbations.

bioRxiv · May 9, 2019 · PreprintImmunology