Author

A. W. Paton

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 5 Biochemistry· 2 Cancer Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 9 Organism:human· 6 Assay:proteomics· 6 Research Focus:cell signaling & trafficking· 5 Organism:mouse· 2 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1

Frequent Co-Authors

J. C. Paton· 9 shared A. Cavalie· 1 shared A. Mendes· 1 shared A. Pottekat· 1 shared A.-M. Lennon-Dumenil· 1 shared B. M. Kessler· 1 shared C. Almeida· 1 shared C. Feliziani· 1 shared

Activity by Year

2019-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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9 shared papersCell Biology

J. C. Paton

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Author profile →

9 papers

Recent·Most cited

Adapting the endoplasmic reticulum proteostasis rescues epilepsy-associated NMDA receptor variants

P.-P. Zhang, T. M. Benske, J. C. Paton, A. W. Paton, T. Mu, Y.-J. Wang

This study shows that enhancing ER proteostasis with BIX rescues the function of epilepsy-linked NMDAR variants by improving their folding and trafficking.

bioRxiv · Apr 1, 2023Cell Biology

Inflammatory cytokines rewire the proinsulin interaction network in human islets

D. Tran, A. Pottekat, K. Lee, M. Raghunathan, S. Loguercio, S. A. Mir, A. W. Paton, J. C. Paton, P. Arvan, R. J. Kaufman, P. Itkin-Ansari

This study identifies how inflammatory cytokines alter the proinsulin interactome in human islets, revealing new interactions and mechanisms involved in diabetes-related proinsulin dysregulation.

bioRxiv · Apr 7, 2022Cell Biology

N-glycolylneuraminic acid serum biomarker levels are elevated in breast cancer patients at all stages of disease.

L. K. Shewell, C. J. Day, J. R. Kutasovic, J. L. Abrahams, J. Wang, J. Poole, C. Niland, K. Ferguson, J. M. Saunus, S. R. Lakhani, M. v. Itzstein, J. C. Paton, A. W. Paton, M. P. Jennings

This study measures Neu5Gc serum biomarker levels in breast cancer patients and finds elevated levels at all disease stages, with high sensitivity and specificity for detection.

bioRxiv · Jun 21, 2021Cancer Biology

Endoplasmic reticulum stress induces a novel Ca2+ signalling system initiated by Ca2+ microdomains

C. Feliziani, G. Quassollo, D. M. Holstein, M. Fernadez, J. C. Paton, A. W. Paton, J. D. Lechleiter, M. Bollo

The paper identifies a novel Ca2+ signalling system in ER stress initiated by Ca2+ microdomains in human astrocytes and IP3R-deficient cells.

bioRxiv · Oct 7, 2020 · PreprintCell Biology

Developmentally regulated PERK activity renders dendritic cells insensitive to subtilase cytotoxin-induced integrated stress response

P. Pierre, A. Mendes, J. P. Gigan, C. Rodriguez Rodrigues, S. A. Choteau, D. Sanseau, D. Barros, C. Almeida, V. Camosseto, L. Chasson, A. W. Paton, J. C. Paton, R. J. Argüello, A.-M. Lennon-Dumenil, E. Gatti

The paper shows dendritic cells have high eIF2 phosphorylation due to PERK activation, but this does not lead to chronic ISR or translation arrest, allowing them to adapt to stress.

bioRxiv · Apr 27, 2020 · PreprintImmunology

Interaction mapping of endoplasmic reticulum ubiquitin ligases identifies modulators of innate immune signalling

E. J. Fenech, F. Lari, P. D. Charles, R. Fischer, M. Laetitia-Thezenas, K. Bagola, A. W. Paton, J. C. Paton, M. Gyrd-Hansen, B. M. Kessler, J. C. Christianson

The paper maps interactions of ER ubiquitin ligases and identifies a complex involving RNF26 that modulates innate immune signaling via the cGAS-STING pathway.

bioRxiv · Mar 18, 2020Cell Biology

The interdomain helix between the kinase and RNase domains of IRE1α transmits the conformational change that underlies ER stress-induced activation.

D. Ricci, S. Tutton, I. Marrocco, M. Ying, D. Blumenthal, D. Eletto, J. Vargas, S. Boyle, H. Fazelinia, J. C. Paton, A. W. Paton, C.-H. A. Tang, C.-C. A. Hu, T. Gidalevitz, Y. Argon

This study identifies the interdomain helix between IRE1α kinase and RNase domains as critical for transmitting conformational changes during ER stress, revealing its role in regulating oligomerization, RNase activity, and kinase function.

bioRxiv · Jan 14, 2020 · PreprintBiochemistry

Proteomics identifies signal peptide features determining the substrate specificity in human Sec62/Sec63-dependent ER protein import

R. Zimmermann, S. Lang, S. Schorr, S. Hassdenteufel, A. Cavalie, M. Greiner, P. Weissgerber, J. Dudek, D. Nguyen, V. Helms, F. Foerster, N. Nagaraj, J. C. Paton, A. W. Paton, M. Molinari, M. Loi

bioRxiv · Dec 6, 2019 · PreprintBiochemistry

IRE1β negatively regulates IRE1α signaling in response to endoplasmic reticulum stress

M. J. Grey, E. Cloots, M. S. Simpson, N. LeDuc, Y. Serebrenik, H. De Luca, D. De Sutter, P. Luong, J. R. Thiagarajah, A. W. Paton, J. C. Paton, M. Seeliger, S. Eyckerman, S. Janssens, W. I. Lencer

This study shows IRE1β suppresses IRE1α signaling during ER stress by blocking its activation and disrupting a feedback loop that regulates IRE1 expression.

bioRxiv · Mar 23, 2019Cell Biology