Author

W. I. Lencer

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 4 Biophysics· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cell signaling & trafficking· 4 Research Focus:host-pathogen & immune response· 4 Organism:mouse· 3 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

H. De Luca· 3 shared J. R. Thiagarajah· 3 shared M. J. Grey· 3 shared M. S. Simpson· 2 shared P. Luong· 2 shared A. K. Kenworthy· 1 shared A. M. Kabbani· 1 shared A. Ringel· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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3 shared papersCell Biology

H. De Luca

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Bacterial Sphingolipids Exacerbate Colitis by Inhibiting ILC3-derived IL-22 Production.

B. Bao, Y. Wang, P. Boudreau, X. Song, M. Wu, X. Chen, I. Patik, Y. Tang, J. D. Ouahed, A. Ringel, J. Barends, C. Wu, E. P. Balskus, J. R. Thiagarajah, J. Liu, , S. Snapper

This study shows that bacterial sphingolipids worsen colitis by reducing IL-22 production from ILC3 cells in mice.

bioRxiv · Sep 5, 2023Immunology

Structural basis for recognition of unfolded proteins by the ER stress sensor ERN1/IRE1α

M. S. Simpson, H. De Luca, S. Cauthorn, P. Luong, N. Udeshi, T. Svinkina, S. S. Schmeider, S. A. Carr, M. J. Grey, W. I. Lencer

This study identifies a 7-residue motif in unfolded proteins recognized by IRE1LD, revealing how IRE1 detects misfolded proteins to trigger the UPR.

bioRxiv · Jun 20, 2023 · PreprintCell Biology

The epithelial-specific ER stress sensor IRE1β enables host-microbiota crosstalk to affect colon goblet cell development

M. J. Grey, H. De Luca, D. V. Ward, I. A. M. Kreulen, S. E. Foley, J. R. Thiagarajah, B. A. McCormick, J. R. Turner, W. I. Lencer

This study shows IRE1β is essential for microbiota-induced goblet cell maturation and mucus barrier assembly in the colon, shaping gut microbiota composition through ER stress regulation.

bioRxiv · Jul 28, 2021 · PreprintCell Biology

Structural basis for acyl chain control over glycosphingolipid sorting and vesicular trafficking

S. S. Schmieder, R. Tatituri, M. Anderson, K. Kelly, W. I. Lencer

The paper identifies a structural motif in ceramide acyl chains that determines glycosphingolipid sorting via endocytic pathways and shows its dependence on cholesterol.

bioRxiv · Apr 26, 2021Cell Biology

Structured clustering of the glycosphingolipid GM1 is required for membrane curvature induced by cholera toxin

A. M. Kabbani, K. Raghunathan, W. I. Lencer, A. K. Kenworthy, C. V. Kelly

This study shows that cholera toxin subunit B induces membrane curvature only when bound to multiple GM1 receptors, highlighting the importance of structured clustering for this process.

bioRxiv · Jan 22, 2020Biophysics

IRE1β negatively regulates IRE1α signaling in response to endoplasmic reticulum stress

M. J. Grey, E. Cloots, M. S. Simpson, N. LeDuc, Y. Serebrenik, H. De Luca, D. De Sutter, P. Luong, J. R. Thiagarajah, A. W. Paton, J. C. Paton, M. Seeliger, S. Eyckerman, S. Janssens, W. I. Lencer

This study shows IRE1β suppresses IRE1α signaling during ER stress by blocking its activation and disrupting a feedback loop that regulates IRE1 expression.

bioRxiv · Mar 23, 2019Cell Biology