L. Mamanova

Multimodal profiling reveals tissue-directed signatures of human immune cells altered with age

The paper profiles immune cell RNA and protein expression across tissues and age to identify tissue-specific and age-related immune signatures.

Single cell transcriptomics reveals chondrocyte differentiation dynamics in vivo and in vitro

This study uses single-cell transcriptomics to compare in vitro and in vivo chondrocyte differentiation, identifies off-target differentiation, and improves in vitro protocols by inhibiting FOXO1.

The emergence of goblet inflammatory or ITGB6hi nasal progenitor cells determines age-associated SARS-CoV-2 pathogenesis

The study identifies age-related differences in nasal epithelial cell responses to SARS-CoV-2 infection, showing distinct progenitor cell dynamics in children and elderly.

Early human lung immune cell development and its role in epithelial cell fate

The paper profiles lung immune cells during development using scRNAseq and identifies IL-1β's role in driving epithelial progenitor differentiation.

Single-Cell Atlas of Common Variable Immunodeficiency reveals germinal center-associated epigenetic dysregulation in B cell responses

The paper creates a single-cell atlas of CVID, identifying epigenetic and transcriptional defects in memory B cells and linking them to impaired cell communication.

A spatial multi-omics atlas of the human lung reveals a novel immune cell survival niche

The paper creates a spatial multi-omics lung atlas identifying novel cell types and a survival niche for IgA-secreting plasma cells in submucosal glands.

Cross-tissue immune cell analysis reveals tissue-specific adaptations and clonal architecture across the human body

The paper analyzes immune cell diversity across 15 human tissues using single-cell RNA sequencing and VDJ sequencing, revealing tissue-specific features and clonal architecture of T and B cells.

Cells of the human intestinal tract mapped across space and time

The paper maps human intestinal cell lineages across development and disease, identifying new cell types and functions related to inflammation and immunity.

Rora regulates activated T helper cells during inflammation

This study investigates Rora's role in CD4+ T cells during inflammation, finding it regulates lung inflammation and is controlled by IL-33 and CCL7.

Tumor to normal single cell mRNA comparisons reveal a pan-neuroblastoma cancer cell

The paper compares tumor and normal single-cell mRNA data to show neuroblastoma cells resemble fetal sympathoblasts across diverse samples.

Cellular mRNA signals in human kidney tumors

This study analyzes mRNA signals in 1,300 kidney tumors to determine their differentiation state and origin, finding that childhood tumors show fetal signals while most adult tumors do not, with exceptions in certain cancer types.

A cell atlas of human thymic development defines T cell repertoire formation

This study creates a cell atlas of the human thymus using scRNA-seq, revealing new cell populations and insights into T-cell development and TCR recombination.

Single-cell sequencing reveals a clonal expansion of pro-inflammatory synovial CD8 T cells expressing tissue homing receptors in psoriatic arthritis

The paper identifies clonal expansion of pro-inflammatory CD8 T cells in psoriatic arthritis joints using single-cell sequencing and links them to tissue homing receptors and antigen specificity.