J. S. Bonifacino

This study shows how PI4P and BLOC-1 coordinate to form and stabilize endosomal tubules, essential for membrane remodeling and pathogen trafficking.

This study shows that defective endosome-TGN retrograde transport enhances NLRP3 inflammasome activation in macrophages, leading to increased inflammation and susceptibility to sepsis.

This study shows that the GARP complex is essential for maintaining Golgi glycosylation by stabilizing enzymes and preventing their mislocalization to endolysosomes.

This study identifies Myosin-7B and SLC35B2 as critical regulators of α-Synuclein fibril endocytosis, revealing a distinct pathway involving HSPG interactions and actin dynamics.

This study identifies UBA6 and BIRC6 as negative regulators of autophagy by ubiquitinating LC3B, reducing its availability and impairing autophagic flux.

This study identifies compound heterozygous VPS51 mutations in a patient with neurodevelopmental disorder, showing impaired GARP/EARP complex assembly and lysosomal dysfunction.