R. Jia

Sequential breakdown of the complex Cf-9 leaf mould resistance locus in tomato by Fulvia fulva

This study identifies Avr9B, an effector that allows F. fulva to overcome Cf-9B resistance in tomato, showing sequential breakdown of the Cf-9 locus.

Individual Decision-Making Underlying the Tragedy of the Commons

The paper studies individual decision-making in group resource use, finding that resource overuse is influenced by individual attitudes and remaining resource levels.

Brevicidine, a bacterial non-ribosomally produced cyclic antimicrobial lipopeptide with a unique modus operandi

This study investigates brevicidine's antimicrobial mechanism against AMR Gram-negative pathogens and shows its efficacy in a mouse model.

Integrative HDX-MS enables quantification of the conformational landscape of the sugar transporter XylE

This paper uses integrative HDX-MS and ensemble modeling to quantify conformational states of the sugar transporter XylE under different conditions.

The cytolethal distending toxin modulates cell differentiation and elicits epithelial to mesenchymal transition

This study shows that CdtB induces epithelial to mesenchymal transition in mouse and human cells, promoting cancer progression through increased cell motility and mesenchymal marker expression.

Tracing two causative SNPs reveals SARS-CoV-2 transmission in North America population

The paper identifies two SNPs in SARS-CoV-2 genomes prevalent in North America, traces their origin to Europe, and suggests they could be targets for surveillance and treatment.

Hydrogen-deuterium exchange mass spectrometry captures distinct dynamics upon substrate and inhibitor binding to a transporter

The paper uses HDX-MS, mutagenesis, and MD simulations to show that substrate binding and protonation drive conformational changes in a transporter, while inhibitors prevent this transition.

Negative Regulation of Autophagy by UBA6-BIRC6-Mediated Ubiquitination of LC3

This study identifies UBA6 and BIRC6 as negative regulators of autophagy by ubiquitinating LC3B, reducing its availability and impairing autophagic flux.