D. C. Gershlick

A short sequence targets transmembrane proteins to primary cilia

The paper identifies a short peptide sequence that efficiently targets transmembrane proteins to primary cilia across cell types and develops an image analysis pipeline for automated cilia measurement.

A quantitative pipeline to assess secretion of human leptin coding variants reveals mechanisms underlying leptin deficiencies

This study develops a medium-throughput assay to assess leptin secretion and identifies mutations causing proteasomal degradation or reduced secretion.

The role of the AP-1 adaptor complex in outgoing and incoming membrane traffic

The paper investigates AP-1 function in membrane traffic, showing it retrieves proteins from post-Golgi compartments back to the TGN, similar to COPI's role in the early secretory pathway.

Recruitment of PI4KIIIbeta to the Golgi by ACBD3 is dependent on an upstream pathway of a SNARE complex and golgins

This study identifies two mechanisms for ACBD3 recruitment to the Golgi: an upstream interaction with SCFD1 and a redundant interaction with golgins.

Limited oxygen availability in standard cell culture alters metabolism and function in terminally-differentiated cells

This study shows that increasing oxygen levels in cell culture improves metabolic function and responsiveness in terminally differentiated cells like adipocytes and hepatocytes.

The exocyst complex is an essential component of the mammalian constitutive secretory pathway

This study identifies the exocyst complex as essential for constitutive secretion in mammalian cells by showing its role in carrier fusion and cargo delivery.

Pathogenic mutations in LRRK2 sequester Rab8a to damaged lysosomes and regulate transferrin-mediated iron uptake in microglia

This study shows that LRRK2 mutations sequester Rab8a into lysosomes and disrupt transferrin-mediated iron uptake in microglia, linking LRRK2 dysfunction to iron dysregulation in Parkinson's disease.

A Neurodevelopmental Disorder Caused by Mutations in the VPS51 Subunit of the GARP and EARP Complexes

This study identifies compound heterozygous VPS51 mutations in a patient with neurodevelopmental disorder, showing impaired GARP/EARP complex assembly and lysosomal dysfunction.