Mammalian ANP32A and ANP32B proteins drive alternative avian influenza virus polymerase adaptations
T. P. Peacock, C. M. Sheppard, E. Staller, R. Frise, O. C. Swann, D. Goldhill, J. S. Long, W. S. Barclay
This study identifies alternative PB2 adaptations that enable influenza polymerase to use mammalian ANP32 proteins, with PB2-E627K showing a preference for ANP32B.
bioRxiv · Sep 3, 2020 · PreprintMicrobiology