H. Shelton

Mapping the interaction sites of Influenza A viruses and human complement Factor H

This study maps the interaction sites between Influenza A viruses and human complement Factor H, showing strain-specific effects on viral entry and replication.

Alteration of the chicken upper respiratory microbiota following H9N2 avian influenza virus infection

This study examines how H9N2 avian influenza virus infection affects the upper respiratory microbiota diversity and composition in chickens, finding reduced alpha diversity and persistent microbiota changes during recovery.

A random priming amplification method for whole genome sequencing of SARS-CoV-2 and H1N1 influenza A virus.

This paper compares random priming amplification methods for whole genome sequencing of SARS-CoV-2 and H1N1 influenza A virus, finding that the SISPA method is most effective for non-targeted sequencing.

Co-infection of chickens with H9N2 and H7N9 avian influenza viruses leads to emergence of reassortant H9N9 virus with increased fitness for poultry and enhanced zoonotic potential

Low pathogenic avian influenza virus infection retards colon microbiome diversification in two different chicken lines

This study shows that low pathogenic avian influenza virus infection reduces colon microbiome diversity in two chicken breeds, delaying its recovery.

Defining functional neuraminidase inhibitor drug resistance motifs in avian influenza viruses and the consequential impact on virus fitness in chicken cells.

This study investigates NAI resistance mutations in avian influenza viruses and their impact on virus fitness in chicken cells, finding strain-specific effects and compensatory mutations in HA.

A COVID-19 vaccine candidate using SpyCatcher multimerization of the SARS-CoV-2 spike protein receptor-binding domain induces potent neutralising antibody responses

This study develops a vaccine candidate using SpyCatcher technology to display the SARS-CoV-2 RBD, showing strong neutralizing antibody responses in mice and pigs.

Evaluation of the immunogenicity of prime-boost vaccination with the replication-deficient viral vectored COVID-19 vaccine candidate ChAdOx1 nCoV-19

This study evaluates the immunogenicity of single and booster doses of the ChAdOx1 nCoV-19 vaccine in mice and pigs, finding that a booster significantly enhances antibody responses, especially in pigs.

Contribution of segment 3 to the acquisition of virulence in contemporary H9N2 avian influenza viruses

This paper identifies a single amino acid change in the PA protein of H9N2 avian influenza viruses that enhances virulence and replication in poultry.

PA-X is an avian virulence factor in H9N2 avian influenza virus

This study investigates the role of PA-X in H9N2 avian influenza viruses, finding it enhances replication in mammalian cells and contributes to virulence in chickens.

Cooperative foraging behavior during larval stage affects fitness in Drosophila

This study shows that cooperative foraging in Drosophila larvae delays development but increases adult fitness through larger wings.

Avian ANP32B does not support influenza A virus polymerase and influenza A virus relies exclusively on ANP32A in chicken cells.