Author

C. M. Sheppard

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 5

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 5 Organism:human· 3 Assay:cryo-EM· 1 Assay:electronic health records· 1 Approach:microscopy & imaging analysis· 1 Organism:mouse· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

T. P. Peacock· 5 shared W. S. Barclay· 5 shared E. Staller· 2 shared J. C. Brown· 2 shared O. C. Swann· 2 shared R. Frise· 2 shared A. B. Rasmussen· 1 shared A. Kotecha· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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5 shared papersMicrobiology

T. P. Peacock

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5 papers

Recent·Most cited

Virion morphology and on-virus spike protein structures of diverse SARS-CoV-2 variants

Z. Ke, T. P. Peacock, J. C. Brown, C. M. Sheppard, T. I. Croll, A. Kotecha, D. H. Goldhill, W. S. Barclay, J. A. Briggs

The paper analyzes SARS-CoV-2 variant virion morphology and spike protein structures using cryo-EM, finding no adaptive changes in virion shape but multiple amino acid changes affecting spike conformational dynamics.

bioRxiv · Dec 21, 2023Microbiology

Avian Influenza A Virus polymerase can utilise human ANP32 proteins to support cRNA but not vRNA synthesis

O. C. Swann, A. B. Rasmussen, T. P. Peacock, C. M. Sheppard, W. S. Barclay

The paper shows avian influenza polymerase uses human ANP32 for cRNA synthesis but requires avian ANP32 for vRNA synthesis, highlighting a difference in ANP32's role in viral replication steps.

bioRxiv · Jun 27, 2022 · PreprintMicrobiology

The SARS-CoV-2 variants associated with infections in India, B.1.617, show enhanced spike cleavage by furin

T. P. Peacock, C. M. Sheppard, J. C. Brown, N. Goonawardane, J. Zhou, M. Whiteley, PHE Virology Consortium, T. I. de Silva, W. S. Barclay

This study shows SARS-CoV-2 B.1.617 variants have enhanced spike cleavage by furin due to the P681R mutation, potentially increasing transmissibility and pathogenicity.

bioRxiv · May 28, 2021 · PreprintMicrobiology

Mammalian ANP32A and ANP32B proteins drive alternative avian influenza virus polymerase adaptations

T. P. Peacock, C. M. Sheppard, E. Staller, R. Frise, O. C. Swann, D. Goldhill, J. S. Long, W. S. Barclay

This study identifies alternative PB2 adaptations that enable influenza polymerase to use mammalian ANP32 proteins, with PB2-E627K showing a preference for ANP32B.

bioRxiv · Sep 3, 2020 · PreprintMicrobiology

A rare variant in ANP32B impairs influenza virus replication in human cells

E. Staller, L. Baillon, R. Frise, T. P. Peacock, C. M. Sheppard, V. Sancho-Shimizu, W. S. Barclay

This study identifies a rare variant in ANP32B that impairs influenza virus replication by disrupting FluPol dimer formation and function.

bioRxiv · Apr 6, 2020Microbiology