Collagen remodeling dictates pancreatic cancer bioenergetics and outcome through DDR1 activation or degradation
H. Su, F. Yang, R. Fu, B. Trinh, N. Sun, J. Liu, A. Kumar, J. Baglieri, J. Siruno, S. Dozier, A. Nair, A. Filliol, S. B. Rosenthal, J. Santini, C. M. Metallo, , M. Karin
This study shows that collagen remodeling via MMP cleavage affects pancreatic cancer bioenergetics and outcome through DDR1 activation or degradation, with distinct impacts on tumor growth and survival.
bioRxiv · Apr 2, 2022 · PreprintCancer Biology