A. M. Lowy

Glutamine mimicry suppresses tumor progression through asparagine metabolism in pancreatic ductal adenocarcinoma

This study shows that DON inhibits PDAC growth by targeting asparagine metabolism, and combining DON with ASNase reduces metastasis.

Bone Morphogenetic Protein (BMP) signaling upregulates expression of ID1 and ID3 in pancreatitis and pancreatic ductal adenocarcinoma

This study identifies BMP signaling as a driver of ID1 and ID3 upregulation in pancreatitis and PDAC, linking it to poor patient survival and disease progression.

A pancreatic cancer mouse model with human immunity

This paper introduces a mouse model of metastatic human pancreatic cancer infiltrated by human immune cells to study tumor immune microenvironment and treatment responses.

Tumor-resident regulatory T cells in pancreatic cancer express the αvβ5 integrin as a targetable activation marker

This study identifies αvβ5 integrin as a marker for activated tumor-resident Tregs in PDAC, showing that targeting it enhances immune checkpoint therapy.

Integrated Molecular Characterization of Intraductal Papillary Mucinous Neoplasms: An NCI Cancer Moonshot Precancer Atlas Pilot Project

This study integrates genomic and transcriptomic analysis of intraductal papillary mucinous neoplasms (IPMNs) to identify molecular features associated with progression to high-grade lesions and cancer.

Collagen remodeling dictates pancreatic cancer bioenergetics and outcome through DDR1 activation or degradation

This study shows that collagen remodeling via MMP cleavage affects pancreatic cancer bioenergetics and outcome through DDR1 activation or degradation, with distinct impacts on tumor growth and survival.