Author

J. T. McCrone

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 5 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Assay:whole-genome sequencing· 5 Approach:statistical model· 4 Research Focus:variant calling· 4 Organism:human· 3 Organism:virus· 2 Approach:Bayesian inference· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

A. S. Lauring· 5 shared A. S. Monto· 4 shared E. T. Martin· 3 shared R. J. Woods· 3 shared J. G. Petrie· 2 shared A. L. Valesano· 1 shared A. O'Toole· 1 shared A. Rambaut· 1 shared

Activity by Year

2016-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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5 shared papersMicrobiology

A. S. Lauring

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Author profile →

6 papers

Recent·Most cited

The effective population size and mutation rate of influenza A virus in acutely infected individuals

J. T. McCrone, R. J. Woods, E. T. Martin, A. S. Monto, A. S. Lauring

The paper estimates the within-host effective population size and mutation rate of influenza A virus in acute infections using sequence data from 200 patients.

bioRxiv · Oct 24, 2020 · PreprintMicrobiology

Accommodating individual travel history, global mobility, and unsampled diversity in phylogeography: a SARS-CoV-2 case study.

P. Lemey, S. Hong, V. Hill, G. Baele, C. Poletto, V. Colizza, A. O'Toole, J. T. McCrone, K. G. Andersen, M. Worobey, M. I. Nelson, A. Rambaut, M. A. Suchard

This paper integrates travel history data into Bayesian phylogeographic analysis of SARS-CoV-2 to improve virus spread reconstructions and address sampling bias.

bioRxiv · Jun 22, 2020 · PreprintEvolutionary Biology

Influenza B viruses exhibit lower within-host diversity than influenza A viruses in human hosts

A. L. Valesano, W. J. Fitzsimmons, J. T. McCrone, J. G. Petrie, A. S. Monto, E. T. Martin, A. S. Lauring

This study compares within-host genetic diversity between influenza B and A viruses, finding lower diversity in B viruses and a tight transmission bottleneck.

bioRxiv · Oct 2, 2019Microbiology

A speed-fidelity trade-off determines the mutation rate and virulence of an RNA virus

W. Fitzsimmons, R. J. Woods, J. T. McCrone, A. Woodman, J. J. Arnold, M. Yennawar, R. Evans, C. E. Cameron, A. S. Lauring

This study shows that RNA viruses evolve high mutation rates as a byproduct of selection for faster replication, not because of adaptive advantages.

bioRxiv · Apr 27, 2018Microbiology

Stochastic processes dominate the within and between host evolution of influenza virus

J. T. McCrone, R. J. Woods, E. T. Martin, R. E. Malosh, A. S. Monto, A. S. Lauring

This study uses viral sequence data from a community-based cohort to estimate within-host population dynamics and transmission bottlenecks of influenza A virus, finding that stochastic processes dominate its evolution.

bioRxiv · Nov 25, 2017Microbiology

Vaccination has minimal impact on the intrahost diversity of H3N2 influenza viruses

K. Debbink, J. T. McCrone, J. G. Petrie, R. Truscon, E. Johnson, E. K. Mantlo, A. S. Monto, A. S. Lauring

This study examines the effect of seasonal influenza vaccination on intrahost diversity of H3N2 viruses using whole genome sequencing and finds minimal impact.

bioRxiv · Nov 7, 2016Microbiology