Author

J. T. Schiffer

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Immunology· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 4 Organism:human· 3 Research Focus:cell type annotation· 2 Assay:bulk RNA-seq· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Assay:metagenomics· 1 Organism:non-human primate· 1

Frequent Co-Authors

E. R. Duke· 3 shared D. B. Reeves· 2 shared E. F. Cardozo-Ojeda· 2 shared A. Goyal· 1 shared A. Lopez· 1 shared A. M. Spivak· 1 shared A. Wald· 1 shared B. T. Mayer· 1 shared

Activity by Year

2018-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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3 shared papersMicrobiology

E. R. Duke

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Mathematical modeling explains differential SARS CoV-2 kinetics in lung and nasal passages in remdesivir treated rhesus macaques

A. Goyal, E. R. Duke, E. F. Cardozo-Ojeda, J. T. Schiffer

The paper develops a mathematical model to explain why remdesivir reduces SARS-CoV-2 viral loads more in lungs than nasal passages in rhesus macaques.

bioRxiv · Jun 21, 2020 · PreprintMicrobiology

Thresholds for post-rebound SHIV control after CCR5 gene-edited autologous hematopoietic cell transplantation

E. F. Cardozo-Ojeda, E. R. Duke, C. W. Peterson, D. B. Reeves, B. T. Mayer, H.-P. Kiem, J. T. Schiffer

This study identifies thresholds for post-rebound SHIV control after CCR5 gene-edited autologous HSPC transplantation using a mathematical model.

bioRxiv · Mar 12, 2020Microbiology

Complementing 16S rRNA gene amplicon sequencing with estimates of total bacterial load to infer absolute species concentrations in the vaginal microbiome

F. Tettamanti Boshier, S. Srinivasan, A. Lopez, N. G. Hoffman, S. Proll, D. N. Fredricks, J. T. Schiffer

The paper combines 16S rRNA gene amplicon sequencing with total bacterial load estimates to infer absolute species concentrations in the vaginal microbiome, showing good correlation with targeted qPCR for relative abundances above 10%.

bioRxiv · Apr 5, 2019Microbiology

Increased oral Epstein-Barr virus shedding with HIV-1 co-infection is due to a combination of B cell activation and impaired cellular immune control

C. M. Byrne, C. Johnson, J. Orem, F. Okuku, M.-L. Huang, S. Selke, A. Wald, L. Corey, J. T. Schiffer, C. Casper, D. Coombs, S. Gantt

This study finds that HIV-1 co-infection increases oral EBV shedding due to B cell activation and weakened cellular immune control, validated through mathematical modeling.

bioRxiv · Mar 24, 2019 · PreprintPathology

A majority of HIV persistence during antiretroviral therapy is due to infected cell proliferation

D. B. Reeves, E. R. Duke, T. A. Wagner, S. E. Palmer, A. M. Spivak, J. T. Schiffer

The paper uses ecological methods to show that most HIV-infected cells during ART arise from proliferation, not new infections, suggesting proliferation reduction could decrease the viral reservoir.

bioRxiv · Sep 7, 2018Immunology