Author

H.-P. Kiem

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 4 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:non-human primate· 4 Research Focus:cell type annotation· 3 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

S. Radtke· 4 shared M. Enstrom· 2 shared A. Berger· 1 shared A. Kumanogoh· 1 shared A. M. Ali· 1 shared A. M. Perez· 1 shared A. Perez· 1 shared A. Pradeep· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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4 shared papersCell Biology

S. Radtke

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Multiplex Base Editing to Protect from CD33-Directed Therapy: Implications for Immune and Gene Therapy

F. Borot, O. Humbert, G. A. Newby, E. Fields, S. Kohli, S. Radtke, G. S. Laszlo, T. Mayuranathan, A. M. Ali, M. J. Weiss, J. S. Yen, R. B. Walter, D. R. Liu, S. Mukherjee, H.-P. Kiem

The paper develops a base editing approach to reduce on-target toxicity in CD33-directed therapies by editing CD33 and gamma globin genes in hematopoietic stem and progenitor cells.

bioRxiv · Feb 23, 2023 · PreprintCell Biology

Myeloid-biased HSC require Semaphorin 4A from the bone marrow niche for self-renewal under stress and life-long persistence

D. Toghani, S. Zeng, E. Mahammadov, E. I. Crosse, N. Seyedhassantehrani, C. Burns, D. Gravano, S. Radtke, H.-P. Kiem, S. Rodriguez, N. Carlesso, A. Pradeep, N. K. Wilson, S. J. Kinston, B. Gottgens, , L. Silberstein

This study identifies Sema4A as a critical niche factor required for myeloid-biased HSC self-renewal and long-term persistence under stress.

bioRxiv · Jan 12, 2022 · PreprintCell Biology

Hematopoietic recovery after transplantation is primarily derived from the stochastic contribution of hematopoietic stem cells

S. Radtke, M. Enstrom, D. P. Pande, M. L. Cui, R. Madhu, A. Perez, H.-P. Kiem

The paper tracks clonal diversity in hematopoietic stem cells after transplantation and finds that HSCs contribute stochastically to early recovery rather than through two distinct phases.

bioRxiv · Sep 21, 2021Cell Biology

Sort-purification of human CD34+CD90+ cells reduces target cell population and improves lentiviral transduction

S. Radtke, D. Pande, M. Cui, A. M. Perez, Y.-Y. Chan, M. Enstrom, S. Schmuck, A. Berger, T. Eunson, J. E. Adair, H.-P. Kiem

This study compares CD34+CD90+ cell purification to other HSC-enrichment strategies, showing it reduces target cells but improves lentiviral transduction and engraftment.

Molecular Therapy - Methods & Clinical Development · Sep 1, 2020Peer-reviewedCell Biology

Thresholds for post-rebound SHIV control after CCR5 gene-edited autologous hematopoietic cell transplantation

E. F. Cardozo-Ojeda, E. R. Duke, C. W. Peterson, D. B. Reeves, B. T. Mayer, H.-P. Kiem, J. T. Schiffer

This study identifies thresholds for post-rebound SHIV control after CCR5 gene-edited autologous HSPC transplantation using a mathematical model.

bioRxiv · Mar 12, 2020Microbiology