Author

M.-L. Huang

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 5 Pathology· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Assay:whole-genome sequencing· 2 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:clustering· 1 Approach:deep learning· 1

Frequent Co-Authors

A. L. Greninger· 3 shared H. Xie· 3 shared A. Addetia· 2 shared S. Gantt· 2 shared A. Greninger· 1 shared A. Nalla· 1 shared A. Wald· 1 shared B. D. Kirkpatrick· 1 shared

Activity by Year

2017-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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3 shared papersMicrobiology

A. L. Greninger

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Multiple independent acquisitions of ACE2 usage in MERS-related coronaviruses

C.-B. Ma, C. Liu, Y.-J. Park, J. Tang, J. Chen, Q. Xiong, J. Lee, C. Stewart, D. Asarnow, J. Brown, M. A. Tortorici, X. Yang, Y.-H. Sun, Y.-M. Chen, X. Yu, , H. Yan

The paper identifies two European bat MERS-related coronaviruses that use ACE2 as their receptor, revealing a distinct binding mode and host tropism determinants.

bioRxiv · Oct 2, 2023Microbiology

In vivo generation of BK and JC polyomavirus defective viral genomes in human urine samples associated with higher viral loads

A. Addetia, Q. Phung, B. T. Bradley, M. Lin, H. Zhu, H. Xie, M.-L. Huang, A. L. Greninger

The paper identifies defective viral genomes (DVGs) in clinical urine samples of BK and JC polyomaviruses, showing their association with higher viral loads and genomic rearrangements.

bioRxiv · Feb 12, 2021Microbiology

Comparative Genomics and Full-Length TprK Profiling of Treponema pallidum subsp. pallidum Reinfection

A. Addetia, L. C. Tantalo, M. J. Lin, H. Xie, M.-L. Huang, C. Marra, A. L. Greninger

The paper compares genomic sequences and full-length TprK profiles of two T. pallidum isolates from the same patient to understand reinfection genetics and immune evasion mechanisms.

PLOS Neglected Tropical Diseases · Apr 6, 2020Peer-reviewedMicrobiology

DIRECT RT-qPCR DETECTION OF SARS-CoV-2 RNA FROM PATIENT NASOPHARYNGEAL SWABS WITHOUT AN RNA EXTRACTION STEP

E. A. Bruce, M.-L. Huang, G. A. Perchetti, S. Tighe, J. J. Hoffman, P. Laaguiby, D. L. Gerrard, A. Nalla, Y. Wei, A. L. Greninger, S. A. Diehl, D. J. Shirley, D. G. B. Leonard, C. D. Huston, B. D. Kirkpatrick, , J. W. Botten

This paper tests a direct RT-qPCR method for detecting SARS-CoV-2 RNA in nasal swabs without RNA extraction, achieving 92% accuracy on blinded samples.

bioRxiv · Mar 20, 2020Microbiology

Increased oral Epstein-Barr virus shedding with HIV-1 co-infection is due to a combination of B cell activation and impaired cellular immune control

C. M. Byrne, C. Johnson, J. Orem, F. Okuku, M.-L. Huang, S. Selke, A. Wald, L. Corey, J. T. Schiffer, C. Casper, D. Coombs, S. Gantt

This study finds that HIV-1 co-infection increases oral EBV shedding due to B cell activation and weakened cellular immune control, validated through mathematical modeling.

bioRxiv · Mar 24, 2019 · PreprintPathology

Genomic and proteomic analysis of Human herpesvirus 6 reveals distinct clustering of acute versus inherited forms and reannotation of reference strain

A. Greninger, G. Knudsen, P. Roychoudhury, D. Hanson, R. A. Hall Sedlak, H. Xie, J. Guan, T. Nguyen, V. Peddu, M. Boeckh, M.-L. Huang, L. Cook, D. Depledge, D. Zerr, D. Koelle, , K. Jerome

This study sequences HHV-6B and iciHHV-6 genomes, identifies geographic clustering and recombination in active infections, and reannotates the HHV-6B genome using transcriptomics and proteomics.

bioRxiv · Aug 27, 2017Microbiology