A novel HIV triple broadly neutralizing antibody (bNAb) combination-based passive immunization of infant rhesus macaques achieves durable protective plasma neutralization levels and mediates anti-viral effector functions.
S. Dankwa, C. Kosman, M. Dennis, E. E. Giorgi, K. Vuong, I. Pahountis, A. Garza, J. McCarthy, B. T. Mayer, J. T. Ngo, C. A. Enemuo, D. G. Carnathan, S. Stanfield-Oakley, S. J. Berendam, C. Weinbaum, , R. Goswami
This study evaluates a triple bNAb combination in infant rhesus macaques, showing durable neutralization and effector functions with high predicted prevention efficacy against HIV strains.
PLOS ONE · Nov 11, 2024Peer-reviewedImmunology