Author

K. W. Huynh

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biochemistry· 2 Biophysics· 2

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 4 Assay:cryo-EM· 3 Research Focus:protein structure prediction· 3 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Organism:human· 1 Approach:microscopy & imaging analysis· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

S. Han· 3 shared A. Samanta· 2 shared B. Bosbach· 2 shared B. Orris· 2 shared D. J. Shields· 2 shared J. T. Stivers· 2 shared R. A. Pumroy· 2 shared T. E. T. Hughes· 2 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersBiochemistry

S. Han

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Guanine-containing ssDNA and RNA induce dimeric and tetrameric SAMHD1 in cryo-EM and binding studies

B. Orris, M. W. Sung, S. Bhat, Y. Xu, K. W. Huynh, S. Han, D. C. Johnson, B. Bosbach, D. J. Shields, J. T. Stivers

This study shows that guanine-containing ssDNA and RNA induce dimeric or tetrameric SAMHD1, with tetramers being inactive for dNTPase and RNase activity.

bioRxiv · Jun 15, 2023 · PreprintBiochemistry

Phosphorylation of SAMHD1 Thr592 increases C-terminal domain dynamics, tetramer dissociation, and ssDNA binding kinetics

B. Orris, K. W. Huynh, M. Ammirati, S. Han, B. Bolanos, J. Carmody, M. D. Petroski, B. Bosbach, D. J. Shields, J. T. Stivers

This study shows that phosphorylation of SAMHD1 at Thr592 increases tetramer dynamics and ssDNA binding, leading to rapid inactivation of dNTPase activity at stalled replication forks.

bioRxiv · Apr 5, 2022Biochemistry

Molecular mechanism of TRPV2 channel modulation by cannabidiol

R. A. Pumroy, A. Samanta, Y. Liu, T. E. T. Hughes, S. Zhao, Y. Yudin, K. W. Huynh, Z. H. Zhou, T. Rohacs, S. Han, V. Y. Moiseenkova-Bell

This study determines the structure of TRPV2 bound to cannabidiol, revealing a unique binding site and the role of the S4-S5 linker in channel gating.

bioRxiv · May 24, 2019Biophysics

Structural insights on TRPV5 gating by endogenous modulators

T. E. T. Hughes, R. A. Pumroy, A. T. Yazici, M. A. Kasimova, E. C. Fluck, K. W. Huynh, A. Samanta, S. Molugu, Z. H. Zhou, V. Carnevale, T. Rohacs, V. Y. Moiseenkova-Bell

The paper determines TRPV5 structures with endogenous modulators PI(4,5)P2 and CaM, revealing their mechanisms of activation and inhibition.

bioRxiv · Jul 31, 2018Biophysics