Author

M. W. Sung

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biochemistry· 3 Biophysics· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Assay:cryo-EM· 4 Approach:experimental assay· 4 Research Focus:protein structure prediction· 4 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:microscopy & imaging analysis· 1

Frequent Co-Authors

S.-L. Shyng· 3 shared B. L. Patton· 2 shared B. Mostofian· 2 shared D. M. Zuckerman· 2 shared Z. Yang· 2 shared B. Bosbach· 1 shared B. Kandasamy· 1 shared B. Orris· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersBiochemistry

S.-L. Shyng

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Guanine-containing ssDNA and RNA induce dimeric and tetrameric SAMHD1 in cryo-EM and binding studies

B. Orris, M. W. Sung, S. Bhat, Y. Xu, K. W. Huynh, S. Han, D. C. Johnson, B. Bosbach, D. J. Shields, J. T. Stivers

This study shows that guanine-containing ssDNA and RNA induce dimeric or tetrameric SAMHD1, with tetramers being inactive for dNTPase and RNase activity.

bioRxiv · Jun 15, 2023 · PreprintBiochemistry

Ligand-mediated structural dynamics of a mammalian pancreatic KATP channel

M. W. Sung, C. M. Driggers, B. Mostofian, J. D. Russo, B. L. Patton, D. M. Zuckerman, S.-L. Shyng

The paper investigates how ligands affect the structural dynamics of pancreatic KATP channels using cryo-EM and molecular dynamics simulations.

bioRxiv · Mar 2, 2022Biochemistry

Vascular KATP channel structural dynamics reveal regulatory mechanism by Mg-nucleotides

M. W. Sung, Z. Yang, B. L. Patton, B. Mostofian, J. Russo, D. M. Zuckerman, S.-L. Shyng

The paper determines cryoEM structures of vascular KATP channels bound to Mg-nucleotides and reveals a conformational pathway for activation.

bioRxiv · May 15, 2021Biochemistry

Mechanism of pharmacochaperoning in KATP channels revealed by cryo-EM

G. M. Martin, M. W. Sung, Z. Yang, L. M. Innes, B. Kandasamy, L. David, C. Yoshioka, S.-L. Shyng

This study reveals how pharmacochaperones stabilize KATP channels by binding to SUR1 and supporting Kir6.2 N-terminus insertion, enabling mutant channel assembly.

bioRxiv · Mar 8, 2019 · PreprintBiophysics