Author

D. C. Johnson

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:cryo-EM· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Approach:microscopy & imaging analysis· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

A. R. Griswold· 1 shared B. Bosbach· 1 shared B. Orris· 1 shared C. Y. Taabazuing· 1 shared D. A. Bachovchin· 1 shared D. J. Shields· 1 shared D. P. Ball· 1 shared E. L. Orth· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperImmunology

A. R. Griswold

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Author profile →

2 papers

Recent·Most cited

Guanine-containing ssDNA and RNA induce dimeric and tetrameric SAMHD1 in cryo-EM and binding studies

B. Orris, M. W. Sung, S. Bhat, Y. Xu, K. W. Huynh, S. Han, D. C. Johnson, B. Bosbach, D. J. Shields, J. T. Stivers

This study shows that guanine-containing ssDNA and RNA induce dimeric or tetrameric SAMHD1, with tetramers being inactive for dNTPase and RNase activity.

bioRxiv · Jun 15, 2023 · PreprintBiochemistry

Human caspase-1 autoproteolysis is required for ASC-dependent and -independent inflammasome activation

D. P. Ball, C. Y. Taabazuing, A. R. Griswold, E. L. Orth, S. D. Rao, I. B. Kotliar, D. C. Johnson, D. A. Bachovchin

This study shows that pro-caspase-1 autoproteolysis is required for both ASC-dependent and -independent inflammasome activation in human cells.

bioRxiv · Jun 24, 2019 · PreprintImmunology