Author

J. Tosello

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Assay:CRISPR screen· 1 Assay:imaging· 1

Frequent Co-Authors

e. piaggio· 2 shared A. Basto· 1 shared A. Darbois· 1 shared A. Kilbey· 1 shared a. mencattini· 1 shared A. Sutra Del Galy· 1 shared c. lansche· 1 shared C. Peres· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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2 shared papersCancer Biology

e. piaggio

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Ex vivo quantification of anti-tumor T-cell activity upon anti-PD-1 treatment in patient-derived lung tumor-on-chip

i. veith, a. mencattini, m. nurmik, i. damei, c. lansche, s. brosseau, g. gropplero, s. corgnac, j. filippi, n. pote, p. mordant, j. tosello, c. sedlik, e. piaggio, n. girard, , M. C. PARRINI

This study develops and validates lung-tumor-on-chip platforms to measure ex vivo anti-PD-1 treatment effects on T-cell activity using live imaging and image analysis.

bioRxiv · Jun 21, 2023 · PreprintCancer Biology

Specialized Tfh cell subsets driving type-1 and type-2 humoral responses in lymphoid tissue

S. Kumar, A. Basto, F. Ribeiro, S. S. C. P. Almeida, P. Campos, C. Peres, S. Al-Khalidi, A. Kilbey, J. Tosello, E. Piaggio, M. Russo, M. Gama-Carvalho, S. B. Coffelt, E. W. Roberts, H. Florindo, L. Graca

The paper identifies specialized Tfh1 and Tfh2 subsets driving type-1 and type-2 humoral responses using single-cell transcriptomics and machine learning.

bioRxiv · Jul 28, 2022Immunology

In vivo genome-wide CRISPR screens identify SOCS1 as a major intrinsic checkpoint of CD4+ Th1 cell response

A. Sutra Del Galy, S. Menegatti, J. Fuentealba, F. Lucibello, J. Helft, A. Darbois, M. Saitakis, J. Tosello, D. Rookhuizen, L. Perrin, M. Deloger, P. Gestraud, G. Socie, S. Amigorena, O. Lantz, L. Menger

The paper identifies SOCS1 as a key intrinsic checkpoint limiting CD4+ Th1 cell response through in vivo CRISPR screens and shows targeting SOCS1 enhances antitumor T-cell therapy.

bioRxiv · Apr 12, 2021Immunology