Author

E. W. Roberts

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 6 Cancer Biology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Organism:mouse· 6 Research Focus:host-pathogen & immune response· 5 Research Focus:cell type annotation· 3 Assay:imaging· 3 Assay:bulk RNA-seq· 2 Assay:flow cytometry· 2 Organism:human· 2

Frequent Co-Authors

C. Nixon· 2 shared F. Fercoq· 2 shared M. F. Krummel· 2 shared N. K. Serwas· 2 shared S. Al-Khalidi· 2 shared S. B. Coffelt· 2 shared A. Basto· 1 shared A. Collins· 1 shared

Activity by Year

2018-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersImmunology

C. Nixon

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

IFNgamma-dependent remodelling of the myeloid landscape underlies control of IFNgamma-insensitive tumours

V. W. C. Lau, G. Mead, J. M. Mazet, A. Krishnan, E. W. Roberts, G. Prota, U. Gileadi, V. Cerundolo, A. Gerard

The paper shows that IFN-gamma-insensitive tumours can still be controlled by immune responses, with IFN-gamma driving myeloid cell remodelling that enhances anti-tumour immunity.

bioRxiv · Mar 25, 2024Immunology

Integrin conformation-dependent neutrophil slowing obstructs the capillaries of the pre-metastatic lung in a model of breast cancer

F. Fercoq, G. S. Cairns, M. De Donatis, J. B. Mackey, A. Floerchinger, A. J. McFarlane, X. L. Raffo-Iraolagoitia, D. Whyte, L. W. Arnott, C. Nixon, R. Wiesheu, L. Brown, S. Al-Khalidi, J. C. Norman, E. W. Roberts, , L. M. Carlin

This study shows that integrin conformation-dependent neutrophil slowing in pre-metastatic lungs obstructs capillaries and may contribute to immunosuppression in breast cancer.

bioRxiv · Mar 19, 2024Immunology

Lung influenza virus specific memory CD4 T cell location and optimal cytokine production are dependent on interactions with lung antigen-presenting cells

K. E. Hargrave, J. C. Worrell, C. Pirillo, E. Brennan, A. Masdefiol Garriga, J. I. Gray, T. Purnell, E. W. Roberts, M. K. MacLeod

bioRxiv · Sep 19, 2023Immunology

Tumour mitochondrial DNA mutations drive aerobic glycolysis to enhance checkpoint blockade

M. Mahmood, E. M. Liu, A. L. Shergold, E. Tolla, J. Tait-Mulder, A. H. Uribe, E. Shokry, A. L. Young, S. Lilla, M. Kim, T. Park, J. L. Manchon, C. Rodriguez-Antona, R. C. Walters, R. J. Springett, , P. A. Gammage

This study shows that mitochondrial DNA mutations in complex I genes drive aerobic glycolysis, enhancing immune checkpoint blockade response in tumors.

bioRxiv · Mar 21, 2023 · PreprintCancer Biology

Specialized Tfh cell subsets driving type-1 and type-2 humoral responses in lymphoid tissue

S. Kumar, A. Basto, F. Ribeiro, S. S. C. P. Almeida, P. Campos, C. Peres, S. Al-Khalidi, A. Kilbey, J. Tosello, E. Piaggio, M. Russo, M. Gama-Carvalho, S. B. Coffelt, E. W. Roberts, H. Florindo, L. Graca

The paper identifies specialized Tfh1 and Tfh2 subsets driving type-1 and type-2 humoral responses using single-cell transcriptomics and machine learning.

bioRxiv · Jul 28, 2022Immunology

CXCR2 inhibition enables NASH-HCC immunotherapy

J. Leslie, J. B. G. Mackey, T. Jamieson, E. Ramon-Gil, T. M. Drake, F. Fercoq, W. Clark, K. Gilroy, A. Hedley, C. Nixon, S. Luli, M. Laszczewska, R. Pinyol, R. Esteban-Fabro, C. E. Willoughby, , Carlin

This study shows that combining CXCR2 inhibition with anti-PD1 therapy enhances immunotherapy response in NASH-HCC by reprogramming tumor-associated neutrophils.

bioRxiv · Feb 24, 2022Cancer Biology

Impact of Protein Identity on Tumor-Associated Antigen Uptake into Infiltrating Immune Cells: A Comparison of Different Fluorescent Proteins as Model Antigens

R. Yi, E. Chen, E. W. Roberts, M. F. Krummel, N. K. Serwas

This study compares six fluorescent proteins as model antigens to assess their uptake and distribution in tumor-infiltrating immune cells and draining lymph nodes, finding variability in detection and transport based on fluorophore properties.

bioRxiv · Oct 30, 2021 · PreprintImmunology

Tumors Exploit Dedicated Intracellular Vesicles to Program T cell Responses

E. W. Roberts, M. K. Ruhland, E. Cai, A. M. Mujal, K. Marchuk, C. Beppler, D. Nam, N. K. Serwas, M. Binnewies, M. F. Krummel

The paper shows myeloid cells transfer tumor antigen-laden vesicles to APCs, directing T cell responses away from memory phenotypes.

bioRxiv · Jul 4, 2019 · PreprintImmunology

Chimeric antigen receptors that trigger phagocytosis

M. A. Morrissey, A. P. Williamson, A. M. Steinbach, E. W. Roberts, N. Kern, M. B. Headley, R. D. Vale

This paper introduces CAR-Ps, chimeric antigen receptors that direct macrophages to engulf specific targets like cancer cells, showing over 40% reduction in cancer cell numbers in co-culture.

bioRxiv · May 16, 2018Cell Biology