S. Amigorena

Epigenetic control of CD8+ T cell tissue homing and tissue resident memory T cell precursors by the histone methyltransferase SUV39H1

This study shows that SUV39H1 depletion in CD8+ T cells enhances tissue homing and TRM differentiation, improving therapeutic outcomes in infection and cancer.

Plasma cell maintenance and antibody secretion are under the control of Sec22b-mediated regulation of organelle dynamics

This study identifies Sec22b as a critical regulator of plasma cell maintenance and function by controlling organelle dynamics, leading to reduced antibody secretion and impaired immune response.

Induction of transposable element expression is central to innate sensing

The paper shows that exogenous PAMPs epigenetically activate LINE1 TEs, which engage cGAS to enhance innate immune responses.

In vivo genome-wide CRISPR screens identify SOCS1 as a major intrinsic checkpoint of CD4+ Th1 cell response

The paper identifies SOCS1 as a key intrinsic checkpoint limiting CD4+ Th1 cell response through in vivo CRISPR screens and shows targeting SOCS1 enhances antitumor T-cell therapy.

Contribution of resident and circulating precursors to tumor-infiltrating CD8+ T cell populations in non-small cell lung cancer patients

The paper identifies two CD8+ TIL subpopulations in NSCLC, one circulating and one resident, which transition into terminally differentiated cells through a unique state.

Small molecule enhancers of endosome-to-cytosol import augment anti-tumour immunity

The paper identifies small molecule enhancers of endosome-to-cytosol antigen import that improve cross-presentation and anti-tumour immunity.

Surface LSP1 is a phenotypic marker distinguishing human classical versus monocyte-derived dendritic cells