Author

J. Totenhagen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

A. M. Carter· 2 shared C. Tan· 2 shared J. A. Bibb· 2 shared R. Telange· 2 shared S. Reddy· 2 shared A. Chakraborti· 1 shared A. G. Sorace· 1 shared A. Guo· 1 shared

Activity by Year

2021-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersCancer Biology

A. M. Carter

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Author profile →

3 papers

Recent·Most cited

Genetic Impairment of Succinate Metabolism Disrupts Bioenergetic Sensing in Adrenal Neuroendocrine Cancer

P. Gupta, K. Strange, R. Telange, A. Guo, H. Hatch, A. Sobh, J. Elie, A. M. Carter, J. Totenhagen, C. Tan, Y. A. Sonawane, J. Neuzil, A. Natarajan, A. J. Ovens, J. S. Oakhill, , J. A. Bibb

This paper shows that loss of SDHB in adrenal neuroendocrine cancer disrupts bioenergetic sensing through Cdk5 activation, leading to tumor progression, and that Cdk5 inhibition can reverse this process.

bioRxiv · Jan 9, 2022Cancer Biology

RORγt-Expressing Pathogenic CD4+T Cells Cause Brain Inflammation During Chronic Colitis

R. Basu, M. E. Mickael, S. Bhaumik, A. Chakraborti, A. Umfress, T. van Groen, M. Macaluso, J. Totenhagen, A. G. Sorace, J. A. Bibb, D. G. Standaert

This study shows that RORγt-expressing CD4+T cells contribute to brain inflammation and neurobehavioral disorders in chronic colitis.

bioRxiv · Sep 1, 2021Immunology

Cdk5 drives formation of heterogeneous pancreatic neuroendocrine tumors

A. M. Carter, N. Kumar, B. Herring, C. Tan, R. Guenter, R. Telange, W. Howse, F. Viol, C. Graham, T. R. McCaw, h. Bickerton, F. Gillardon, E. A. Woltering, J. Totenhagen, R. Banerjee, , J. Bibb

This paper develops a mouse model of PanNETs driven by Cdk5 and shows its relevance to human tumors, supporting Cdk5 as a therapeutic target.

bioRxiv · May 25, 2021Cancer Biology