Author
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
5 papers
Recent·Most cited
C. Kasap, A. Izgutdina, B. Patino-Escobar, A. Kang, N. Chilakapati, N. Akagi, H. Johnson, T. Rashid, J. Werner, A. Barpanda, H. Geng, Y.-H. T. Lin, S. Rampersaud, D. Gil-Alos, A. Sobh, , A. Wiita
Structure-optimized CD27-based CAR-T cells targeting CD70 show >80-fold improved expansion in vivo and offer a potential therapy for high-risk multiple myeloma patients.
bioRxiv · Feb 24, 2024Cancer Biology
D. Dupere-Richer, A. Riva, S. Maji, B. G. Barwick, H. Casella, A. Sobh, G. Quickstad, J. Li, u. de, C. Piper, M. Kulis, T. Ezponda, I. Martin-Subero, G. Tonon, W. Zhang, , J. D. Licht
This study shows KDM6A regulates immune response genes in multiple myeloma by activating NLRC5 and CIITA, and its loss reduces MHC expression, which can be reversed by HDAC3 inhibitors.
bioRxiv · Feb 12, 2024Cancer Biology
J. Pei, Y. Xiao, X. Liu, W. Hu, A. Sobh, Y. Yuan, S. Zhou, N. Hua, S. G. Mackintosh, X. Zhang, K. B. Basso, M. Kamat, Q. Yang, J. D. Licht, G. Zheng, , D. Lv
The paper identifies piperlongumine as a covalent E3 ligase recruiter that, when conjugated with CDK9 inhibitors, induces targeted protein degradation of CDK9 and EML4-ALK fusion oncoprotein.
bioRxiv · Jan 21, 2022Cancer Biology
P. Gupta, K. Strange, R. Telange, A. Guo, H. Hatch, A. Sobh, J. Elie, A. M. Carter, J. Totenhagen, C. Tan, Y. A. Sonawane, J. Neuzil, A. Natarajan, A. J. Ovens, J. S. Oakhill, , J. A. Bibb
This paper shows that loss of SDHB in adrenal neuroendocrine cancer disrupts bioenergetic sensing through Cdk5 activation, leading to tumor progression, and that Cdk5 inhibition can reverse this process.
bioRxiv · Jan 9, 2022Cancer Biology
M. Grodzki, A. P. Bluhm, M. Schafer, A. Tagmount, M. Russo, A. Sobh, R. Rafiee, C. D. Vulpe, S. M. Karst, M. H. Norris
Genome-wide CRISPR screens identified host factors that promote human coronavirus infection, revealing novel antiviral drug targets.
bioRxiv · Jun 4, 2021Microbiology