Author

A. J. Ovens

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cancer Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell signaling & trafficking· 2 Organism:mouse· 2 Assay:proteomics· 2 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

J. S. Oakhill· 3 shared J. W. Scott· 2 shared A. Guo· 1 shared A. Hoque· 1 shared A. M. Carter· 1 shared A. M. Ehrlich· 1 shared A. Natarajan· 1 shared A. Sobh· 1 shared

Activity by Year

2021-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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3 shared papersCancer Biology

J. S. Oakhill

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3 papers

Recent·Most cited

Genetic Impairment of Succinate Metabolism Disrupts Bioenergetic Sensing in Adrenal Neuroendocrine Cancer

P. Gupta, K. Strange, R. Telange, A. Guo, H. Hatch, A. Sobh, J. Elie, A. M. Carter, J. Totenhagen, C. Tan, Y. A. Sonawane, J. Neuzil, A. Natarajan, A. J. Ovens, J. S. Oakhill, , J. A. Bibb

This paper shows that loss of SDHB in adrenal neuroendocrine cancer disrupts bioenergetic sensing through Cdk5 activation, leading to tumor progression, and that Cdk5 inhibition can reverse this process.

bioRxiv · Jan 9, 2022Cancer Biology

Novel torin1-sensitive phosphorylation sites on the metabolic regulator AMPK revealed by label-free mass spectrometry

W. J. Smiles, A. J. Ovens, D. Yu, N. X. Y. Ling, A. Hoque, J. W. Scott, S. Galic, C. G. Langendorf, B. E. Kemp, J. Petersen, J. S. Oakhill

The paper identifies mTORC1-sensitive phosphorylation sites on AMPK using mass spectrometry, revealing their role in regulating nuclear AMPK activity and cell proliferation under nutrient stress.

bioRxiv · Oct 20, 2021 · PreprintBiochemistry

Compound- and fiber type-selective requirement of AMPKγ3 for insulin-independent glucose uptake in skeletal muscle

P. Rhein, E. M. Desjardins, P. Rong, D. Ahwazi, N. Bonhoure, J. Stolte, M. D. Santos, A. J. Ovens, A. M. Ehrlich, J. L. Sanchez Garcia, Q. Ouyang, M. F. Kjolby, M. Membrez, N. Jessen, J. S. Oakhill, , K. Sakamoto

This study shows that AMPKγ3 is essential for AICAR-induced glucose clearance and uptake in glycolytic muscle but not for ADaM drug-induced effects or adipose thermogenesis.

bioRxiv · Mar 5, 2021Physiology