RNA binding to human METTL3-METTL14 restricts N6-deoxyadenosine methylation of DNA in vitro
S. Qi, J. Mota, S.-H. Chan, J. Villarreal, N. Dai, S. Arya, R. A. Hromas, M. K. Rao, I. R. Correa, Y. K. Gupta
This study investigates how the METTL3-METTL14 complex binds and methylates DNA and RNA, revealing distinct preferences for single-stranded DNA and structured RNA.
bioRxiv · Jan 8, 2022Biochemistry