Engineering CAR-NK cells to secrete IL15 sustains their anti-AML functionality, but is associated with systemic toxicities
I. Christodoulou, W. J. Ho, A. Marple, J. W. Ravich, A. Tam, R. Rahnama, A. Fearnow, C. Rietberg, S. Yanik, E. E. Solomou, R. Varadhan, M. A. Koldobskiy, C. L. Bonifant
This study shows that engineering NK cells to secrete IL15 improves their anti-AML activity but causes systemic toxicities.
bioRxiv · Sep 23, 2021 · PreprintImmunology