Author

W. J. Ho

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Immunology· 2 Bioengineering· 1 Pathology· 1 Plant Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:human· 5 Assay:bulk RNA-seq· 3 Research Focus:cell type annotation· 3 Research Focus:host-pathogen & immune response· 3 Assay:imaging· 3 Organism:mouse· 3 Research Focus:cancer & tumor microenvironment· 2

Frequent Co-Authors

A. Hernandez· 3 shared E. M. Coyne· 3 shared J. W. Lee· 3 shared M. Yarchoan· 3 shared S. M. Shin· 3 shared A. Matsui· 2 shared D. G. Duda· 2 shared E. J. Fertig· 2 shared

Activity by Year

2020-2024 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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3 shared papersCancer Biology

A. Hernandez

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Author profile →

8 papers

Recent·Most cited

Mapping the breast tumor microenvironment: proximity analysis reveals spatial relationships between macrophage subtypes and metastasis-initiating cancer cells

E. M. Grasset, A. Desphande, J. W. Lee, Y. Cho, S. M. Shin, E. M. Coyne, A. Hernandez, X. Yuan, A. Cimino-Matthews, A. J. Ewald, W. J. Ho

The paper uses spatial analysis to show metastasis-initiating cancer cells in breast tumors are closely associated with specific macrophage subtypes, suggesting these interactions promote metastasis.

bioRxiv · Mar 15, 2024Cancer Biology

Liver fibrosis uncouples tumor control from survival after multikinase inhibitor immunotherapy in hepatocellular carcinoma

S. Morita, T. Ando, H. Kikuchi, A. Morita, T. Kobayashi, G. Birch, R. Tanaka, A. Matsui, Z. Ruan, P. Huang, Y. Cho, A. Hernandez, J. W. Lee, E. M. Coyne, S. M. Shin, , D. G. Duda

Liver fibrosis limits the survival benefit of multikinase inhibitor immunotherapy in hepatocellular carcinoma by promoting innate immune-mediated hepatotoxicity despite preserved tumor control.

bioRxiv · Oct 20, 2023 · PreprintCancer Biology

Immune landscape of tertiary lymphoid structures in hepatocellular carcinoma (HCC) treated with neoadjuvant immune checkpoint blockade

D. H. Shu, W. J. Ho, L. T. Kagohara, A. Girgis, S. M. Shin, L. Danilova, J. W. Lee, D. N. Sidiropoulos, S. Mitchell, K. Munjal, K. Howe, K. J. Bendinelli, H. Qi, G. Mo, J. Montagne, , M. Yarchoan

This study examines TLS in HCC treated with neoadjuvant immunotherapy, finding TLS correlate with better outcomes and show distinct morphological and functional features in tumor regression.

bioRxiv · Oct 16, 2023 · PreprintImmunology

Informing virtual clinical trials of hepatocellular carcinoma with spatial multi-omics analysis of a human neoadjuvant immunotherapy clinical trial

S. Zhang, A. Deshpande, B. K. Verma, H. Wang, H. Mi, L. Yuan, W. J. Ho, E. M. Jaffee, Q. Zhu, R. A. Anders, M. Yarchoan, L. T. Kagohara, E. J. Fertig, A. S. Popel

The paper develops a spatial quantitative systems pharmacology model for virtual clinical trials in HCC, validated with spatial multi-omics data from a neoadjuvant immunotherapy trial.

bioRxiv · Aug 11, 2023 · PreprintBioengineering

Reprogramming Intrahepatic Cholangiocarcinoma Immune Microenvironment by Chemotherapy and CTLA-4 Blockade Enhances Anti-PD1 Therapy

J. Chen, Z. Amoozgar, X. LIU, S. Aoki, Z. Liu, S. Shin, A. Matsui, Z. Pu, P.-J. Lei, M. Datta, L. Zhu, Z. Ruan, L. Shi, D. Staiculescu, K. Inoue, , D. G. Duda

This paper shows that combining chemotherapy with CTLA-4 blockade reprograms the immune microenvironment of intrahepatic cholangiocarcinoma, enhancing the effectiveness of anti-PD1 therapy.

bioRxiv · Jan 26, 2023Cancer Biology

Engineering CAR-NK cells to secrete IL15 sustains their anti-AML functionality, but is associated with systemic toxicities

I. Christodoulou, W. J. Ho, A. Marple, J. W. Ravich, A. Tam, R. Rahnama, A. Fearnow, C. Rietberg, S. Yanik, E. E. Solomou, R. Varadhan, M. A. Koldobskiy, C. L. Bonifant

This study shows that engineering NK cells to secrete IL15 improves their anti-AML activity but causes systemic toxicities.

bioRxiv · Sep 23, 2021 · PreprintImmunology

15-PGDH Regulates Hematopoietic and Gastrointestinal Fitness During Aging

W. J. Ho, J. N. P. Smith, Y. S. Park, M. Hadiono, K. F. Christo, A. Jogasuria, Y. Zhang, A. V. Broncano, L. Kasturi, D. M. Dawson, S. L. Gerson, S. D. Markowitz, A. B. Desai

This study shows that 15-PGDH inhibition improves hematopoietic and gastrointestinal tissue fitness in aged mice by enhancing regeneration and reducing inflammation.

bioRxiv · Dec 22, 2020 · PreprintPathology

Regulation of CYP94B1 by WRKY33 controls apoplastic barrier formation in the roots leading to salt tolerance

P. Krishnamurthy, B. Vishal, W. J. Ho, F. C. J. Lok, F. S. M. Lee, P. P. Kumar

The paper shows that AtWRKY33 regulates AtCYP94B1 to enhance suberin deposition in Arabidopsis root endodermal cells, improving salt tolerance.

bioRxiv · Aug 10, 2020Plant Biology