R. D. Cummings

Recognition of highly branched N-glycans of the porcine whipworm by the immune system

The paper identifies N-glycans from the porcine whipworm Trichuris suis that are recognized by the immune system and exhibit species-specific features.

Platelet-Localized ST6Gal1 Does Not Impact IgG Sialylation

This study investigates whether platelet-localized ST6Gal1 affects IgG sialylation and finds no significant impact.

Plasma ST6Gal1 is Dispensable for IgG Sialylation

The paper shows that plasma ST6Gal1 is not required for IgG 2,6-sialylation, as IgG sialylation remains normal in mice lacking ST6Gal1 in hepatocytes or B cells.

A Useful Guide to Lectin Binding: Machine-Learning Directed Annotation of 57 Unique Lectin Specificities

The paper uses machine learning and manual annotation to define the glycan-binding specificities of 57 lectins based on microarray data.

Endogenous Galectin-3 is Required for Skeletal Muscle Repair

This study shows that endogenous galectin-3 is essential for skeletal muscle repair and myogenic programming in mice.

Galectin-1-deficient mice are protected against Trypanosoma cruzi infection through altered neutrophil migration and production of reactive oxygen species and nitric oxide

This study shows that Galectin-1 deficiency in mice reduces T. cruzi parasitemia and increases survival by enhancing neutrophil migration and reactive oxygen species/nitric oxide production.

SARS-CoV-2 Spike Protein Interacts with Multiple Innate Immune Receptors

This study identifies multiple innate immune receptors that recognize SARS-CoV-2 spike protein through glycan-dependent interactions, suggesting potential therapeutic targets.

Mucin glycans signal through the sensor kinase RetS to inhibit virulence-associated traits in Pseudomonas aeruginosa

This study shows that mucin glycans activate RetS in Pseudomonas aeruginosa, inhibiting virulence traits by suppressing the GacS-GacA system and type VI secretion system.

Resident and elicited macrophages differ in expression of their glycomes and lectins

The paper compares glycome and lectin gene expression between resident and elicited macrophages, finding differences in glycan types and lectin gene expression.

Differential glycosylation of alpha-1-acid glycoprotein (AGP-1) contributes to its functional diversity.

This study shows that differential glycosylation of AGP-1 leads to distinct functional effects on neutrophils and platelets during inflammation.

The schizophrenia risk locus in SLC39A8 alters brain metal transport and plasma glycosylation

The paper investigates how a common SLC39A8 variant affects brain metal transport and plasma glycosylation in schizophrenia, identifying manganese-related changes and potential biomarkers.

Glycosylation of Zika Virus Is Important in Host-Virus Interaction and Pathogenesis

This study maps N-glycans on ZIKV E proteins and shows their role in viral entry via host lectins, highlighting their importance in pathogenesis.

A library of structurally homogeneous human N-glycans synthesized from microbial oligosaccharide precursors

This paper describes a bioenzymatic method to synthesize homogeneous human N-glycans from microbial precursors, enabling efficient production of glycan structures for glycoscience applications.