Author

J.-C. Guillemot

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cell Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 3 Research Focus:drug response / drug discovery· 2 Research Focus:host-pathogen & immune response· 2 Assay:bulk RNA-seq· 1 Assay:structural biology· 1

Frequent Co-Authors

B. Canard· 3 shared C. Eydoux· 3 shared A. Shannon· 2 shared B. Selisko· 2 shared V. Fattorini· 2 shared A. Jacquet· 1 shared A. K. N. Chan· 1 shared A. Kannt· 1 shared

Activity by Year

2020-2021 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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Curved chords = mutual co-authorship

3 shared papersBiochemistry

B. Canard

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Simeprevir suppresses SARS-CoV-2 replication and synergizes with remdesivir

H. S. Lo, K. P. Y. Hui, H.-M. Lai, K. S. Khan, S. Kaur, J. Huang, Z. Li, A. K. N. Chan, H. H.-Y. Cheung, K. C. Ng, J. C. W. Ho, Y. W. Chen, B. Ma, P. M.-H. Cheung, D. Shin, , W.-L. Ng

The paper identifies simeprevir as a potent inhibitor of SARS-CoV-2 replication that synergizes with remdesivir in vitro.

ACS Central Science · Apr 15, 2021Peer-reviewedMicrobiology

Protein-primed RNA synthesis in SARS-CoVs and structural basis for inhibition by AT-527

A. Shannon, V. Fattorini, B. Sama, B. Selisko, M. Feracci, C. Falcou, P. Gauffre, P. El Kazzi, E. Decroly, N. Rabah, K. Toulon, C. Eydoux, J.-C. Guillemot, M. Noel, F. Debart, , B. Canard

This paper identifies a protein-priming mechanism for SARS-CoV RNA synthesis and shows that AT-527 inhibits this process by targeting both NiRAN and RdRp domains.

bioRxiv · Mar 23, 2021Biochemistry

A Fluorescence-based High Throughput-Screening assay for the SARS-CoV RNA synthesis complex

C. Eydoux, V. Fattorini, A. Shannon, T.-T.-N. Le, B. Didier, B. Canard, J.-C. Guillemot

The paper describes a fluorescence-based high-throughput screening assay for identifying inhibitors of the SARS-CoV RNA synthesis complex using a purified and active replication/transcription complex.

Journal of Virological Methods · Feb 1, 2021Peer-reviewedBiochemistry

A 3D human liver model of nonalcoholic steatohepatitis

M. Duriez, L. Hoet, A. Jacquet, S. Roche, M.-D. Bock, C. Rocher, G. Haussy, X. Vige, Z. Bocskei, T. Slavnic, V. Martin, J.-C. Guillemot, M. Didier, A. Kannt, C. Orsini, , A.-C. Le Fevre

The paper develops a 3D human liver model of nonalcoholic steatohepatitis that can be used for drug screening and disease study.

bioRxiv · Feb 7, 2020Cell Biology