Author

V. Fattorini

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 2 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Assay:structural biology· 1

Frequent Co-Authors

A. Shannon· 3 shared B. Canard· 3 shared B. Selisko· 2 shared C. Eydoux· 2 shared E. Decroly· 2 shared F. Ferron· 2 shared J.-C. Guillemot· 2 shared T.-T.-N. Le· 2 shared

Activity by Year

2020-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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3 shared papersBiochemistry

A. Shannon

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Author profile →

3 papers

Recent·Most cited

Protein-primed RNA synthesis in SARS-CoVs and structural basis for inhibition by AT-527

A. Shannon, V. Fattorini, B. Sama, B. Selisko, M. Feracci, C. Falcou, P. Gauffre, P. El Kazzi, E. Decroly, N. Rabah, K. Toulon, C. Eydoux, J.-C. Guillemot, M. Noel, F. Debart, , B. Canard

This paper identifies a protein-priming mechanism for SARS-CoV RNA synthesis and shows that AT-527 inhibits this process by targeting both NiRAN and RdRp domains.

bioRxiv · Mar 23, 2021Biochemistry

A Fluorescence-based High Throughput-Screening assay for the SARS-CoV RNA synthesis complex

C. Eydoux, V. Fattorini, A. Shannon, T.-T.-N. Le, B. Didier, B. Canard, J.-C. Guillemot

The paper describes a fluorescence-based high-throughput screening assay for identifying inhibitors of the SARS-CoV RNA synthesis complex using a purified and active replication/transcription complex.

Journal of Virological Methods · Feb 1, 2021Peer-reviewedBiochemistry

Favipiravir strikes the SARS-CoV-2 at its Achilles heel, the RNA polymerase

A. Shannon, B. Selisko, T.-T.-N. Le, J. Huchting, F. Touret, G. Piorkowski, V. Fattorini, F. Ferron, E. Decroly, C. Meier, B. Coutard, O. Peersen, B. Canard

This study shows Favipiravir inhibits SARS-CoV-2 by targeting its RNA polymerase through chain termination, slowed synthesis, and mutagenesis.

bioRxiv · May 15, 2020 · PreprintBiochemistry