Author

K. C. Ng

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Organism:mouse· 1 Assay:proteomics· 1 Organism:virus· 1

Frequent Co-Authors

J. C. W. Ho· 2 shared K. P. Y. Hui· 2 shared M. C. W. Chan· 2 shared A. Bertoletti· 1 shared A. Chia· 1 shared A. K. N. Chan· 1 shared A. T. Tan· 1 shared B. Canard· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersMicrobiology

J. C. W. Ho

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Mutation nsp6 L232F associated with MERS-CoV zoonotic transmission confers higher viral replication in human respiratory tract cultures ex-vivo

R. T. So, D. K. W. Chu, K. P. Y. Hui, C. K.-P. Mok, S. Sanyal, J. M. Nicholls, J. C. W. Ho, M. C. Cheung, K. C. NG, H. W. Yeung, M. C. W. Chan, L. L. M. Poon, J. Zhao, J. S. M. Peiris

This study identifies the nsp6 L232F mutation in MERS-CoV as enhancing viral replication in human respiratory tissues and mice, suggesting a role in human adaptation.

bioRxiv · Mar 27, 2023Microbiology

Mutations of SARS-CoV-2 variants of concern escaping Spike-specific T cells

N. Le Bert, A. T. Tan, K. Kunasegaran, A. Chia, N. Tan, Q. Chen, S. K. Hang, M. D. Qui, B. S. Chan, J. G. Low, B. Young, K. C. Ng, D. W. S. Chan, D. C. B. Lye, A. Bertoletti

This study examines how mutations in SARS-CoV-2 variants affect Spike-specific T cell responses, finding that some mutations reduce CD8 T cell recognition while overall T cell responses remain largely intact.

bioRxiv · Jan 20, 2022 · PreprintImmunology

Simeprevir suppresses SARS-CoV-2 replication and synergizes with remdesivir

H. S. Lo, K. P. Y. Hui, H.-M. Lai, K. S. Khan, S. Kaur, J. Huang, Z. Li, A. K. N. Chan, H. H.-Y. Cheung, K. C. Ng, J. C. W. Ho, Y. W. Chen, B. Ma, P. M.-H. Cheung, D. Shin, , W.-L. Ng

The paper identifies simeprevir as a potent inhibitor of SARS-CoV-2 replication that synergizes with remdesivir in vitro.

ACS Central Science · Apr 15, 2021Peer-reviewedMicrobiology