Author

T.-T.-N. Le

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 2 Research Focus:drug response / drug discovery· 1 Organism:virus· 1

Frequent Co-Authors

A. Shannon· 3 shared B. Canard· 3 shared V. Fattorini· 2 shared B. Coutard· 1 shared B. Didier· 1 shared B. Selisko· 1 shared C. E. Cameron· 1 shared C. Eydoux· 1 shared

Activity by Year

2020-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersBiochemistry

A. Shannon

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3 papers

Recent·Most cited

A Fluorescence-based High Throughput-Screening assay for the SARS-CoV RNA synthesis complex

C. Eydoux, V. Fattorini, A. Shannon, T.-T.-N. Le, B. Didier, B. Canard, J.-C. Guillemot

The paper describes a fluorescence-based high-throughput screening assay for identifying inhibitors of the SARS-CoV RNA synthesis complex using a purified and active replication/transcription complex.

Journal of Virological Methods · Feb 1, 2021Peer-reviewedBiochemistry

Inhibition of SARS-CoV-2 polymerase by nucleotide analogs: a single moleculeperspective

M. Seifert, S. C. Bera, P. van Nies, R. N. Kirchdoerfer, A. Shannon, T.-T.-N. Le, X. Meng, H. Xia, J. M. Wood, L. D. Harris, F. S. Papini, J. J. Arnold, S. C. Almo, T. L. Grove, P.-Y. Shi, , D. Dulin

This study investigates how nucleotide analogs like Remdesivir affect SARS-CoV-2 polymerase activity using single-molecule techniques, revealing backtracking rather than termination and evasion of ddhCTP.

bioRxiv · Aug 6, 2020 · PreprintBiophysics

Favipiravir strikes the SARS-CoV-2 at its Achilles heel, the RNA polymerase

A. Shannon, B. Selisko, T.-T.-N. Le, J. Huchting, F. Touret, G. Piorkowski, V. Fattorini, F. Ferron, E. Decroly, C. Meier, B. Coutard, O. Peersen, B. Canard

This study shows Favipiravir inhibits SARS-CoV-2 by targeting its RNA polymerase through chain termination, slowed synthesis, and mutagenesis.

bioRxiv · May 15, 2020 · PreprintBiochemistry