Author

P. El Kazzi

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:structural biology· 2 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

B. Canard· 2 shared E. Decroly· 2 shared A. Brancale· 1 shared A. L. W. van Vliet· 1 shared A. Moussa· 1 shared A. Shannon· 1 shared B. Coutard· 1 shared B. Sama· 1 shared

Activity by Year

2021-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersMicrobiology

B. Canard

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Fluoxetine targets an allosteric site in the enterovirus 2C AAA+ ATPase and stabilizes the hexameric complex

D. L. Hurdiss, P. El Kazzi, L. Bauer, N. Papageorgiou, F. P. Ferron, T. Donselaar, A. L. W. van Vliet, B. Canard, E. Decroly, A. Brancale, T. Zeev-Ben-Mordehai, F. Förster, F. J. M. van Kuppeveld, B. Coutard

This study identifies fluoxetine as an inhibitor of the enterovirus 2C AAA+ ATPase, revealing its mechanism of action through structural and functional analyses.

bioRxiv · Apr 26, 2021Microbiology

Protein-primed RNA synthesis in SARS-CoVs and structural basis for inhibition by AT-527

A. Shannon, V. Fattorini, B. Sama, B. Selisko, M. Feracci, C. Falcou, P. Gauffre, P. El Kazzi, E. Decroly, N. Rabah, K. Toulon, C. Eydoux, J.-C. Guillemot, M. Noel, F. Debart, , B. Canard

This paper identifies a protein-priming mechanism for SARS-CoV RNA synthesis and shows that AT-527 inhibits this process by targeting both NiRAN and RdRp domains.

bioRxiv · Mar 23, 2021Biochemistry