Author

J.-L. Imler

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 4 Organism:Drosophila· 3 Organism:Arabidopsis· 1 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Assay:metagenomics· 1

Frequent Co-Authors

D. Chen· 2 shared H. Cai· 2 shared J. Huang· 2 shared J. T. Marques· 2 shared A. Gaye· 1 shared A. Holleufer· 1 shared A. L. C. Cruz· 1 shared A. Lemoine· 1 shared

Activity by Year

2019-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersImmunology

D. Chen

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Author profile →

4 papers

Recent·Most cited

Antiviral RNA interference targets viral transcripts but not genomes of RNA viruses in Drosophila melanogaster

E. Silva, F. Alvaro, T. Leite, I. Faria, J. Armache, G. Hass, F. Martin, J.-L. Imler, J. Marques

The paper identifies polyadenylated viral transcripts as the primary targets of the Drosophila siRNA pathway during RNA virus infection, rather than viral genomes.

bioRxiv · Apr 10, 2024 · PreprintImmunology

A novel virus-induced cyclic dinucleotide, 2'3'-c-di-GMP, mediates STING-dependent antiviral immunity in Drosophila

H. Cai, L. Li, K. Slavik, J. Huang, T. Yin, L. Hedelin, Z. Xiang, Y. Yang, X. Li, Y. Chen, Z. Wei, H. Deng, D. Chen, R. Jiao, N. Martins, , J.-L. Imler

bioRxiv · May 8, 2023Immunology

Insect-specific viruses regulate vector competence in Aedes aegypti mosquitoes via expression of histone H4

R. P. Olmo, Y. M. H. Todjro, E. R. G. R. Aguiar, J. P. P. de Almeida, J. N. Armache, I. J. S. de Faria, F. V. Ferreira, A. T. S. Silva, K. P. R. de Souza, A. P. P. Vilela, C. H. Tan, M. Diallo, A. Gaye, C. Paupy, J. Obame-Nkoghe, , J. T. Marques

This study shows insect-specific viruses in Aedes aegypti mosquitoes increase their susceptibility to arboviruses by preventing histone H4 downregulation.

bioRxiv · Jun 5, 2021Microbiology

2'3'-cGAMP triggers a STING and NF-κB dependent broad antiviral response in Drosophila

H. Cai, A. Holleufer, B. Simonsen, J. Schneider, A. Lemoine, H.-H. Gad, J. Huang, J. Huang, D. Chen, T. Peng, J. T. Marques, R. Hartmann, N. E. Martins, J.-L. Imler

This study shows that 2'3'-cGAMP activates dSTING and NF-κB to trigger a broad antiviral response in Drosophila, independent of autophagy and RNAi pathways.

bioRxiv · Nov 27, 2019Immunology