Modulation of the functional interfaces between retroviral intasomes and the human nucleosome
E. Mauro, D. Lapaillerie, C. Tumiotto, C. Charlier, F. Martins, S. Sousa, M. Metifiot, P. Weigel, K. Yamatsugu, M. Kanai, H. Lehmann, C. Richetta, J. Batisse, M. Ruff, O. Delelis, , V. Parissi
The paper develops an alphaLISA assay to study intasome-nucleosome interactions, identifies compounds that modulate this interaction, and shows their antiviral effects against PFV and HIV-1.
bioRxiv · Sep 29, 2022Microbiology