J.-S. Park

Intermolecular interactions between cysteine and aromatic amino acids with phenyl moiety in the DNA-binding domain of heat shock factor 1 regulate thermal stress-induced trimerization.

This study identifies that the amino acid at residue 103 of HSF1 regulates trimer formation temperature through intermolecular interactions with aromatic residues.

Shear-induced phenotypic transformation of microglia in vitro

This study investigates how fluid shear stress affects microglia morphology and activation, finding that shear flow promotes a shift toward pro-inflammatory states.

Interaction between VPS13A and the XK scramblase is required to prevent VPS13A disease in humans

This study identifies the PH domain of VPS13A as critical for its interaction with XK scramblase, and shows that mutations disrupting this interaction cause VPS13A disease.

Trogocytic-molting of T-cell microvilli controls T-cell clonal expansion

The paper identifies trogocytic-molting as a process where T cells release TCRs via microvilli, leading to increased surface TCRs and metabolic reprogramming to support clonal expansion.

Long-term cellular cargo tracking reveals intricate trafficking through active cytoskeletal networks

The paper tracks unlabeled cargo movement in cells using interferometric scattering microscopy, revealing dynamic trafficking and cytoskeletal network organization.

Phenylpropionc acid produced by gut microbiota alleviates acetaminophen-induced hepatotoxicity

This study shows that phenylpropionic acid from gut microbiota reduces acetaminophen-induced liver damage in mice by inhibiting the toxic enzyme CYP2E1.

Prominin-1-Radixin Axis controls hepatic gluconeogenesis by regulating PKA activity

The paper shows that Prom1 regulates hepatic gluconeogenesis by modulating PKA activity through its interaction with radixin.