H. Jeong

Hidden route of protein damage through confined oxygen gas

The paper identifies a hidden oxidative damage pathway in proteins through O2 confinement and photoexcitation, bypassing antioxidant defenses.

Structure of C. elegans TMC-2 complex suggests roles of lipid-mediated subunit contacts in mechanosensory transduction

The paper presents the cryo-EM structure of the C. elegans TMC-2 complex and compares it to the TMC-1 complex to identify structural features involved in mechanosensory transduction.

The orientation of choroidal macrophage polarization significantly influences the development of myopia in murine models

This study shows that choroidal macrophage polarization direction affects myopia development in mice, with M1 macrophages promoting and M2 macrophages suppressing myopia.

The fingering patterns in the epithelial layer control the gap closure rate via curvature-mediated force

The paper shows that fingering patterns in epithelial layers influence gap closure speed through curvature-mediated forces, with fingering frequency inversely related to boundary curvature.

Multifunctional Materials Strategies for Enhanced Safety of Wireless, Skin-Interfaced Bioelectronic Devices

This paper introduces a self-healing PDMS material with safety-enhancing properties for wireless, skin-interfaced bioelectronic devices.

High-resolution assessment of multidimensional cellular mechanics using label-free refractive-index traction force microscopy

This paper introduces RI-TFM, a high-speed label-free technique for 3D cellular mechanics, and demonstrates its ability to measure traction forces and morphology in cells.

Structure of C. elegans TMC-1 complex illuminates auditory mechanosensory transduction

The paper determines the structure of the C. elegans TMC-1 complex using cryo-EM, revealing its composition and mechanism of mechanosensory transduction.

Dynamic molecular evolution of a supergene with suppressed recombination in white-throated sparrows

The paper studies the evolution of a supergene in white-throated sparrows, finding reduced recombination, low degeneration, and balancing selection maintaining genetic diversity.

Amelioration of DSS-induced Acute Colitis in Mice by Recombinant Monomeric Human Interleukin-22

This study produces recombinant monomeric human IL-22 and shows it reduces DSS-induced colitis and pro-inflammatory cytokines in mice.

Efficacy of double-stranded RNA for the large-scale control and prevention of sacbrood virus in Apis cerana (Hymenoptera: Apidae) apiaries

This study tests the efficacy of double-stranded RNA targeting VP1 to control and prevent sacbrood virus in Apis cerana apiaries, showing increased survival rates and safe mitigation of the virus.

AMPK-dependent phosphorylation is required for transcriptional activation of TFEB/TFE3

This study shows that AMPK-dependent phosphorylation of TFEB/TFE3 enhances their transcriptional activity under nutrient starvation and promotes chemoresistance in cancer.

CRP immunodeposition and proteomic analysis in abdominal aortic aneurysm

This study investigates mCRP deposition in AAA and identifies associated proteomic changes and enriched pathways.

Encoding multiple virtual signals in DNA barcodes with single-molecule FRET

This study encodes multiple virtual signals in DNA barcodes using single-molecule FRET, enabling the differentiation of six barcodes without sequence exchange.

FLCN Gene Ablation Reduces Fibrosis and Inflammation in a Diet-Induced NASH Model

This study shows that FLCN gene ablation reduces fibrosis and inflammation in a diet-induced NASH model by enhancing autophagy and lysosomal biogenesis.

COVID-19 patients upregulate toll-like receptor 4-mediated inflammatory signaling that mimics bacterial sepsis

The paper identifies upregulated TLR4-mediated inflammatory signaling in COVID-19 patients, linking it to pathological inflammation and suggesting TLR4 as a therapeutic target.

Phenylpropionc acid produced by gut microbiota alleviates acetaminophen-induced hepatotoxicity

This study shows that phenylpropionic acid from gut microbiota reduces acetaminophen-induced liver damage in mice by inhibiting the toxic enzyme CYP2E1.

Signature of N-terminal domain (NTD) structural re-orientation in NPC1 for proper alignment of cholesterol transport: Molecular dynamics study with mutation

This study uses molecular dynamics simulations to investigate how the R518W mutation in NPC1 affects its structure and cholesterol transport function, revealing a structural shift in the NTD that may impair NPC2 interaction.

Regenerating motor neurons prime muscle stem cells for myogenesis by enhancing protein synthesis and mitochondrial bioenergetics

This study shows that motor neurons enhance muscle stem cell function by boosting protein synthesis and mitochondrial activity, which is critical for muscle regeneration and is disrupted in diseases like muscular dystrophy and aging.

Living cell-only bioink and photocurable supporting medium for printing and generation of engineered tissues with complex geometries

This paper introduces a cell-only bioink and supporting medium for 3D printing and long-term culture of functional tissues without a biomaterial scaffold.

Commensal gut bacteria convert the immunosuppressant tacrolimus to less potent metabolites

This study identifies gut bacteria, particularly Clostridiales, as a source of tacrolimus metabolism, producing less potent metabolites that may explain variable drug exposure after oral dosing.

Conversion of a soluble protein into a potent chaperone in vivo

This study shows a soluble protein can act as a chaperone in vivo, preventing protein aggregation and aiding folding, similar to known chaperones.