J. H. Shin

Metastasis of colon cancer requires Dickkopf-2 to generate cancer cells with Paneth cell properties

This study shows DKK2 is required for colon cancer metastasis by generating cancer cells with Paneth cell properties through HNF4A regulation.

AI-driven Classification of Cancer-Associated Fibroblasts Using Morphodynamic and Motile Features

This paper introduces an AI framework to classify cancer-associated fibroblasts using morphodynamic and motile features from live-cell imaging, complementing biomolecular approaches.

Differential expression of tension-sensitive HOX genes in fibroblasts is associated with different scar types

The paper identifies differential expression of tension-sensitive HOX genes in fibroblasts across scar types and links it to tensional homeostasis in wound healing.

Dissecting the energetic architecture within an RNA tertiary structural motif via high-throughput thermodynamic measurements

This paper uses high-throughput thermodynamic measurements to analyze the energetic architecture of an RNA tertiary motif, revealing non-linear cooperativity and exceptions to established stability-abundance relationships.

The fingering patterns in the epithelial layer control the gap closure rate via curvature-mediated force

The paper shows that fingering patterns in epithelial layers influence gap closure speed through curvature-mediated forces, with fingering frequency inversely related to boundary curvature.

Shear-induced phenotypic transformation of microglia in vitro

This study investigates how fluid shear stress affects microglia morphology and activation, finding that shear flow promotes a shift toward pro-inflammatory states.

High-resolution assessment of multidimensional cellular mechanics using label-free refractive-index traction force microscopy

This paper introduces RI-TFM, a high-speed label-free technique for 3D cellular mechanics, and demonstrates its ability to measure traction forces and morphology in cells.

A new transcriptional metastatic signature predicts survival in clear cell renal cell carcinoma

The paper identifies a transcriptional signature in primary ccRCC tumors that predicts metastatic potential and patient survival.

Vimentin Intermediate Filaments and Filamentous Actin Form Unexpected Interpenetrating Networks That Redefine the Cell Cortex

This study reveals that vimentin intermediate filaments and F-actin form an interpenetrating network in the cell cortex, enhancing contractile forces and influencing actin dynamics.

Prime editing enables precise genome editing in mouse liver and retina

This study demonstrates that prime editing can correct disease-causing mutations in adult mouse liver and retina, with minimal off-target effects.

Enriching neural stem cell and pro-healing glial phenotypes with electrical stimulation after traumatic brain injury in male rats

This study shows that electrical stimulation after traumatic brain injury in rats promotes pro-healing microglia phenotypes, increases neural stem cells and Nestin+ astrocytes, and enhances neuronal viability.

Fibroblasts close a void in free space by a purse-string mechanism

This study shows fibroblasts can close large artificial wounds using a purse-string mechanism similar to epithelial cells, relying on myosin II and adherent junctions.

High-resolution positron emission microscopy of patient-derived tumor organoids

This paper develops a high-resolution microscopy method to image FDG in tumor organoids, mirroring clinical PET scans and predicting treatment response.

Intestinal-derived FGF15 preserves muscle and bone mass following sleeve gastrectomy

This study shows that intestinal FGF15 protects against muscle and bone loss after sleeve gastrectomy in mice.

The role of elevated branched chain amino acids in the potent effects of vertical sleeve gastrectomy to reduce weight and improve glucose regulation in mice

This study investigates whether reduced branched-chain amino acid (BCAA) levels after vertical sleeve gastrectomy (VSG) contribute to metabolic improvements in mice, finding that BCAA reduction is not necessary for weight loss or glucose tolerance.

Feasibility of real-time in vivo 89Zr-DFO-labeled CAR T-cell trafficking using PET imaging

This paper demonstrates the feasibility of using PET imaging to track 89Zr-DFO-labeled CAR T-cells in vivo, showing their distribution and migration over time.

Integrative analysis of DNA methylation suggests down-regulation of oncogenic pathways and reduced de-novo mutation in survival outliers of glioblastoma

The paper analyzes DNA methylation in glioblastoma survivors to identify distinct methylation patterns linked to oncogenic pathways and mutation rates.

NSD1 inactivation defines an immune cold, DNA hypomethylated subtype in squamous cell carcinoma

This study identifies an NSD1-inactivated, DNA hypomethylated, immune cold subtype in lung and head and neck squamous cell carcinomas, linked to poor immune infiltration and potential immunotherapy resistance.