Transplantation of Human IPSC-derived Microglia Ameliorates Neuropathology and Circuit Dysfunction in Progranulin-Deficient Mice
Hayk Davtyan, Sarah A. Naguib, Yuliya Voskobiynyk, Jean Paul Chadarevian, Joia Kai Capocchi, J.L. Giacchino, Ghazaleh Eskandari‐Sedighi, Vivianna R. DeNittis, Jeremy B. Ford, Ani Agababian, Jasmine Nguyen, Alina L Chadarevian, Madison S. Sutherland, Sepideh Kiani Shabestari, Kayla Nhi Tran, , Li Gan
This study shows that transplanting wild-type human iPSC-derived microglia into progranulin-deficient mice reduces neuropathology, circuit dysfunction, and behavioral issues in a FTD model.
Molecular Neurodegeneration · Jul 16, 2026Peer-reviewedNeuroscience