A late-stage assembly checkpoint of the human mitochondrial ribosome large subunit
Pedro Rebelo‐Guiomar, Simone Pellegrino, Kyle C. Dent, Aldema Sas‐Chen, Leonor Miller‐Fleming, Caterina Garone, Lindsey Van Haute, Jack F. Rogan, Adam M. Dinan, Andrew E. Firth, Byron Andrews, Alexander J. Whitworth, Schraga Schwartz, Alan John Warren, Michal A. Minczuk
This study identifies a late-stage quality control step in human mitochondrial ribosome large subunit assembly, showing that MRM2 ablation impairs oxidative phosphorylation through defective translation and accumulation of assembly intermediates.
Nature Communications · Feb 17, 2022Peer-reviewedMolecular Biology